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. 2022 Jan 6;13(4):565–576. doi: 10.1007/s12975-021-00978-2

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Fig. 1 — A Directed acyclic graph (DAG) demonstrating confounding covariate interaction with exposure (SNP) and outcome — primary analysis. B DAG demonstrating both confounding and selected non-confounding covariates — predictive modelling in cases with available data, for genetic variants confirmed in A. C Pathway diagram demonstrating possible mediation of a gene ➔ outcome effect by WFNS, rebleed or DCI, for genetic variants confirmed in A. SNP, single nucleotide polymorphism; WFNS, World Federation of Neurological Surgeons; aSAH, aneurysmal subarachnoid haemorrhage; DCI, delayed cerebral ischemia