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. 2022 Jun 24;13:3618. doi: 10.1038/s41467-022-31395-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–f Surrogate neutralization activity in different time periods. The horizontal bar indicates the geometric mean level. Dotted horizontal lines represent the manufacturer’s seropositivity cutoff level (15 AU/ml). The geometric mean antibody titer for each age group was compared to the ≥80 years age group using the one way ANOVA with Dunn’s multiple comparisons test. The number of serum specimens tested in each period is shown in Supplementary Table S1. Source data are provided as a Source Data file. NS, not significant.