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. 2022 Jun 24;13:3610. doi: 10.1038/s41467-022-31029-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Experimental parameters: sampling cone 125 V, trap collision energy 25 V, trap DC bias 50 V, trap pressure 4.38 × 10⁻² mbar, and backing pressure 5.88 mbar. a Top panel: native ESI-MS showing oligomers up to 18-mer (18HB). Bottom panel: corresponding drift time plot with different charge states (selected peaks annotated) of the same oligomer size grouped into ellipses. b Collision cross sections (CCS) derived from the measured IM drift times for different oligomer sizes after calibration, using the charge state with the highest peak intensity per group: (monomer (1) 6+, dimer (2) 9+, trimer (3) 11+, tetramer (4) 13+ and (6HB) 16+), at AmAc concentrations of 20 and 1000 mM. Monomer (1) to tetramer (4) shows a near-linear size increase, whilst the hexamer (6HB) is below the linear trend line (dotted), and therefore more compact. Note that the pentamer (5) was not detected.