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. 2021 Jul 1;13(8):559–579. doi: 10.1007/s13238-021-00856-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of human cancers linked to mutations or abnormal expressions of splicing factors and spliceosome genes. Mutated or aberrantly expressed splicing factors and spliceosome genes including FUBP1, FUBP3, HNRNPCL1, PCBP1, PCBP2, PHF5A, QKI, RBM10, SF3B1, and SFPQ, are linked to a variety of solid tumors. While alterations in some other spliceosome genes, e.g., PRPF8, SF3B1, SRSF2, U2AF1, and ZRSR2, are associated with hematologic disorders and malignancies, such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and chronic myelomonocytic leukemia (CMML)