Figure 1.

APPs ameliorated memory impairments triggered by HFD. (A–F) MWM test. (A) The latency to find the hidden platform was measured during training trials (n = 6). (B) Representative images in MWM tests during the probe trials. (C) The distance in target quadrant of mice in the MWM tests (n = 6). (D) Number of platform crossings (n = 6). (E) Escape distance (n = 6). (F) Number of target quadrant crossings (n = 6). (G–M) Y-maze test. (G) Correct alternation rate (n = 6). (H) Total shuttle times (n = 6). (I) Representative images in Y-maze test. (J) Total distance (n = 6). (K)Time in novel arm (n = 6). (L) Percentage of time in novel arm (n = 6). (M) Novel arm movement distance (n=6). Data are presented as mean ± SEM, NS= not significant, *p < 0.05, **p < 0.01, compared with HFD group.

Abbreviations: ARPs, Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides; HFD, high-fat diet; HARPs, HFD + ARPs; MWM, Morris water maze.