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. 2022 Jun 20;16:1931–1945. doi: 10.2147/DDDT.S356934

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© 2022 Fu et al.

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ARPs modulated regulators involved in cognitive function in hippocampus. (A) H&E staining of hippocampus. Nuclear pyknosis of hippocampal neurons were marked with black arrows. Scale bar = 100 μm. (B) Immunofluorescence staining of BDNF in hippocampus. (C)The mRNA levels of Tau and BDNF in mice hippocampus (n = 6). Scale bar = 50 μm. (D) Western blot analysis of BDNF, p-Tau and total Tau in mice hippocampus. (E) The mRNA levels of NQO1, NT3, PSD95 and FGF21 in mice hippocampus (n = 6). Data are presented as mean ± SEM, NS= not significant, *p < 0.05, **p < 0.01 compared with HFD group.

Abbreviations: ARPs, Anoectochilus roxburghii (Wall.) Lindl. Polysaccharides; HFD, high-fat diet; HARPs, HFD + ARPs.