Figure-1:

Comparative description of skin phenotype in normal healthy and HS patients subjects. A. Normal skin; B. HS skin during early disease. Please note that as compared to normal skin, HS skin is hyperproliferative with intense infiltration of inflammatory cells, beginning of hair follicle clogging and disruption. Disease skin microenvironment is also unique with the release of multiple cytokines, ECM components and other clastogens. The localization of keratins that define skin keratinocyte types is also altered in HS Skin. This figure is created with BioRender.com.