Table 1:

Aberrant ECM signaling in various Diseases

ECM Components	Change expression/functions in pathogenesis	Reference
Collagen	CCL18 producing CD163+cells (M2 macrophages) impact dermal fibroblast in promoting production of collagens (such as Col1A1, Col2A1, Col3A1) involving TGFβ and SMAD2/3 signaling	DOI:10.1111/bjd.16600 DOI: 10.1016/S0014-4835(02)00248-8 DOI: 10.4049/jimmunol.0903306 DOI: 10.1074/jbc.M100754200 DOI: 10.3181/00379727-232-2320406 DOI:10.1016/S1074-7613(00)80530-0 DOI: 10.1016/j.molimm.2011.09.006
	Cytokines IL4, IL13 and IL33 secreted by immune cells stimulates synthesis of ECM components. IL13 is important in differentiating fibroblast into myofibroblast, a key step in tissue fibrosis
	Collagen peptides interact with inhibitory LAIR-1 receptors on immune cells to reduce their cytotoxic function associated with epidermal hyperplasia, bacterial infection or nociception
Elastin	In fibrosis, elastin peptides activated fibroblast and augment cytokine production via ERK signaling	DOI: 10.1016/j.patbio.2011.10.006 DOI: 10.1016/s0014-5793(02)03057-0 DOI:10.3390/app11188732
	Elastin peptides act as chemotactic agents regulating tissue trafficking of macrophage and neutrophils
	Elastin peptides induce ROS in immune cells and enhance elastase and MMPs
	Low Elastin concentrations impact T cell proliferation and polarization
Laminin	Laminin plays role in proliferation, migration and adhesion of immune cells	DOI:10.1016/j.it.2017.06.002 DOI:10.3389/fcell.2019.00068
	Laminin fragments/processed peptides act as DAMPs and alter expression of cytokines and MMPs
Fibronectin	Fibronectin and its variants modulate T cells and TLR signaling	DOI: 10.1109/CSPA.2012.6194761 DOI:10.1371/journal.pone.0102974
	Fibronectin regulates secretion of cytokines/chemokines in fibroblasts
ECM-1	ECM-1 secreted by Th2 immune cells affects Th17 responses	DOI: 10.4049/jimmunol.1502457.
	ECM-1 impacts TGFβ signaling