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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Eur Radiol. 2022 Jan 31;32(7):4967–4979. doi: 10.1007/s00330-021-08529-x

Table 3.

Diagnosis of bone marrow metastases on 2-[18F]FDG-PET-MRI, DW-MRI or combined scans, based on reviewer assignments of 650 anatomical regions (10 regions per patient and imaging exam) as either positive or negative for tumor.

Treatment Status Image modality TP FN FP TN Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
Baseline 2-[18F]FDG-PET-MRI 62 3 0 155 95.4 100.0 100.0 98.1 98.6
DW-MRI 57 8 0 155 87.7a 100.0 100.0 95.1 96.4a
Combined 65 0 0 155 100.0b 100.0 100.0 100.0 100.0b
Standard of Reference 65 0 0 155 100.0 100.0 100.0 100.0 100.0
Post-treatment 2-[18F]FDG-PET-MRI 139 17 0 274 89.1 100.0 100.0 94.2 96.0
DW-MRI 140 16 0 274 89.7a 100.0 100.0 94.5 96.3a
Combined 156 0 0 274 100.0b 100.0 100.0 100.0 100.0b
Standard of Reference 156 0 0 274 100.0 100.0 100.0 100.0 100.0
All Lesions 2-[18F]FDG-PET-MRI 201 20 0 429 91.0 100.0 100.0 95.5 96.9
DW-MRI 197 24 0 429 89.1a 100.0 100.0 94.7 96.3a
Combined 221 0 0 429 100.0b 100.0 100.0 100.0 100.0b
Standard of Reference 221 0 0 429 100.0 100.0 100.0 100.0 100.0
a

No statistically significant difference when comparing with 2-[18F]FDG-PET-MRI (p>0.05).

b

Statistically significant difference when comparing with either 2-[18F]FDG-PET-MRI or DW-MRI (p<0.001).

Abbreviations: 2-[18F]FDG-PET-MRI: 2-[18F]fluoro-2-deoxy-D-glucose enhanced positron emission tomography-magnetic resonance imaging, DW-MRI: Diffusion weighted-magnetic resonance imaging, TP: true positive, FN: false negative, FP: false positive, TN: true negative, PPV: positive predictive value, NPV: negative predictive value.