Table 3.
Association of retinal nonperfusion index and nonperfused area with the presence of predominantly peripheral lesions on UWF-color image and on UWF-FA
| Statistics Mean ± SD Median (IQR) |
Presence of Predominantly Peripheral Lesions on UWF-Color |
Presence of Predominantly Peripheral Lesions on UWF-FA |
||||
|---|---|---|---|---|---|---|
| Color-PPL Absent | Color-PPL Present | P Value * | FA-PPL Absent | FA-PPL Present | P Value * | |
| No. of Eyes | 396 | 256 | 370 | 282 | ||
| Nonperfusion Index | ||||||
| Overall | 0.13 ± 0.17 | 0.16 ± 0.17 | 0.65 | 0.12 ± 0.17 | 0.18 ± 0.17 | <0.001 |
| 0.05 (0.00, 0.22) | 0.09 (0.01, 0.27) | 0.03 (0.00, 0.19) | 0.13 (0.03, 0.29) | |||
| By Zones of the Retina | ||||||
| Posterior pole (<10 mm) | 0.05 ± 0.08 | 0.04 ± 0.07 | -- | 0.04 ± 0.08 | 0.04 ± 0.07 | 0.38 |
| 0.01 (0.00, 0.06) | 0.00 (0.00, 0.05) | 0.01 (0.00, 0.05) | 0.01 (0.00, 0.06) | |||
| Mid-periphery (10–15 mm) | 0.15 ± 0.22 | 0.17 ± 0.22 | -- | 0.13 ± 0.21 | 0.19 ± 0.22 | <0.001 |
| 0.02 (0.00, 0.21) | 0.07 (0.00, 0.29) | 0.01 (0.00, 0.18) | 0.09 (0.01, 0.32) | |||
| Far periphery (>15 mm) | 0.25 ± 0.32 | 0.32 ± 0.33 | -- | 0.22 ± 0.31 | 0.36 ± 0.33 | <0.001 |
| 0.04 (0.00, 0.48) | 0.22 (0.00, 0.59) | 0.00 (0.00, 0.41) | 0.30 (0.01, 0.64) | |||
| Nonperfused Area (mm2) | ||||||
| Overall | 105.75 ± 138.01 | 124.37 ± 134.51 | -- | 93.00 ± 133.62 | 139.38 ± 136.79 | -- |
| 38.73 (3.76, 167.93) | 75.40 (4.93, 207.26) | 23.79 (1.96, 155.92) | 98.11 (21.33, 222.59) | |||
| By Zones of the Retina | ||||||
| Posterior pole (<10 mm) | 14.14 ± 24.79 | 11.75 ± 20.22 | -- | 13.14 ± 24.08 | 13.29 ± 21.83 | -- |
| 3.18 (0.19, 16.44) | 1.44 (0.00, 14.68) | 2.74 (0.16, 14.07) | 2.04 (0.00, 16.81) | |||
| Mid-periphery (10–15 mm) | 44.30 ± 67.89 | 52.72 ± 66.50 | -- | 39.05 ± 64.79 | 58.84 ± 69.26 | -- |
| 6.60 (0.26, 65.03) | 21.13 (0.73, 87.23) | 2.93 (0.00, 53.99) | 28.89 (3.99, 95.51) | |||
| Far periphery (>15 mm) | 47.31 ± 61.79 | 59.90 ± 63.81 | -- | 40.82 ± 58.84 | 67.26 ± 64.84 | -- |
| 5.89 (0.00, 93.69) | 38.17 (0.00, 111.99) | 0.76 (0.00, 77.48) | 52.04 (1.21, 120.19) | |||
*
P value obtained from a beta regression model with adjustment for the percentage of imaged area on UWF-FA and the correlation between the two eyes from the same participant. Analyses of nonperfusion index for each retinal zone were performed only when the overall analysis demonstrated a significant association (P < 0.05).
SD, standard deviation; IQR, interquartile range; PPL, predominantly peripheral lesions; UWF, ultrawide field