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. Author manuscript; available in PMC: 2023 Jun 15.
Published in final edited form as: Cell Syst. 2022 Apr 21;13(6):438–453.e5. doi: 10.1016/j.cels.2022.03.006

Figure 4. Stereotyped expansion in the mouse neocortex.

Figure 4.

(A) Consensus cladograms of two P42 mice. Nodes with posterior probability of >0.05 are resolved. Posterior probabilities of >0.10 are indicated. ● LOH event shared among all daughter cells, ▲ LOH event shared in all but one daughter cell.

(B) LOH events by mouse and cell type. Total autosomal LOH events are shown for each cell on the y-axis. Violin plots show event distribution for each cell type in each mouse.

(C) The active X-chromosome is overlaid onto cell lineages of two female mice. The active X-chromosome (square) and cell type (circle) is indicated by color. NC = biparental/not called. For clades composed of either active X-chromosome, the most recent common cell (internal nodes) are inferred to occur about or before the time of gastrulation (when X-inactivation takes place) and their respective preceding branches are colored red. Nodes predicted to occur after the approximate time of gastrulation are shown in black. RGC = radial glia cell, ImmN = immature neuron, Neur = neuron, GlutN = glutamatergic neuron, ImmA = immature astrocyte, Astro = astrocyte, oIPC = oligodendrocyte intermediate progenitor cell, Oligo = oligodendrocyte.