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. Author manuscript; available in PMC: 2022 Jun 25.
Published in final edited form as: JACC Clin Electrophysiol. 2022 Apr 3;8(6):766–778. doi: 10.1016/j.jacep.2022.03.001

Central Illustration: Association of Peri-Device Leak with Thromboembolic Events after LAAO.

Central Illustration:

Among >50,000 patients who underwent LAAO in the US (2016–2019), 1 in 4 patients had peri-device leak detected on follow up imaging at 45 days. Majority of leaks were small <5 mm in diameter. Small leaks, however, we associated with a modest increase in the composite endpoint of stroke, TIA, or SE at 1 year follow up.

LAAO; left atrial appendage occlusion, TIA; transient ischemic attack, SE; systemic embolization, HR; hazard ratio.