Table-4.

Incidence Rates of Adverse Events Stratified by Leak Size

Clinical Outcomes	Leak= 0 mm (N=37,696)	Leak= 0–5 mm (N=13,258)	Leak >5 mm (N= 379)
Ischemic Stroke	1.39% (1.27%–1.52%)	1.61% (1.39%–1.84%)	1.42% (0.18%–2.66%)
Stroke, TIA, or SE	2.98% (2.80%–3.17%)	3.49% (3.16%–3.81%)	3.13% (1.31%–4.94%)
Major Bleeding	7.58% (7.3%–7.86%)	8.57% (8.07%–9.07%)	6.82% (4.19%–9.45%)
Death	5.97% (5.72%–6.23%)	6.41% (5.97%–6.85%)	7.96% (5.13%–10.78%)
Any MAE	17.43% (17.02%–17.83%)	19.44% (18.73%–20.15%)	19.61% (15.46%–23.76%)

TIA; transient ischemic attack, SE; systemic embolization, MASE: major adverse serious event which included death, cardiac arrest, ischemic, hemorrhagic, or undetermined stroke, TIA, SE, major bleeding, major vascular complication (fistula or pseudoaneurysm requiring fibrin injection, angioplasty, or surgical repair), myocardial infarction, pericardial effusion requiring intervention, or device embolization.