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. Author manuscript; available in PMC: 2023 Jun 16.
Published in final edited form as: Mol Cell. 2022 Apr 6;82(12):2215–2227. doi: 10.1016/j.molcel.2022.03.022

Figure 5. Selected ferroptosis-regulatory signaling pathways.

Figure 5.

Lipid metabolism is a complex process regulated by many signaling pathways, and the activation or suppression of these pathways can therefore modulate sensitivity to ferroptosis. The pathways outlined here, not meant to be exhaustive, are a sampling of some of those regulating ferroptosis. Question marks indicate processes that have not been clearly defined mechanistically. For example, it is unclear how HILPDA selectively releases PUFA from lipid droplets, how exactly MUFAs efficiently block ferroptosis, or the exact mechanism underlying how inhibition of ACC (and thus de novo lipogenesis) can inhibit ferroptosis.