. Author manuscript; available in PMC: 2023 Jul 1.

Published in final edited form as: Ann Neurol. 2022 Apr 27;92(1):23–31. doi: 10.1002/ana.26364

Table 2:

Association Between APOE-ɛ4 and High Burden of ePVS by Brain Region

	Odds Ratios (95% CI)
	Centrum Semiovale (CSO)	Basal Ganglia (BG)	Mixed CSO-BG Score^a
Model 1
APOE ε4+	1.45 (1.16, 1.81)^*	1.15 (0.86, 1.53)	1.37 (1.11, 1.68)^*

Model 2
APOE4 ε4+	1.46 (1.16, 1.83)^*	1.19 (0.89, 1.60)	1.38 (1.12, 1.71)^*

ePVS = enlarged perivascular spaces; CSO = centrum semiovale; BG = basal ganglia; CI = confidence interval; FHS = Framingham Heart Study

High burden of ePVS is defined as grades III or IV in the respective region (i.e. counts > 20). Model 1 adjusts for age, sex, time interval between examination and brain MRI, and FHS cohort. Model 2 additionally adjusts for smoking status, diabetes, and hypertension status. Binary logistic regression was used for high burden of ePVS in the CSO and BG regions. Ordinal logistic regression was used for CSO-BG mixed score where probabilities were cumulated over higher outcome values.

p < 0.05

Number of CSO-BG regions with high ePVS burden (0=none, 1=one region, or 2=both regions)