Table 4.

Exploratory Analyses of the Association Between High Burden of ePVS and Cerebral Microbleed Presence by Brain Region

	Odds Ratio (95% CI)
Location	Any CMB	Strictly Lobar	Strictly Deep	Deep or Lobar
Centrum Semiovale (CSO)a	1.08 (0.61, 1.93)	0.94 (0.50, 1.78)	2.64 (1.02, 6.88)*	3.22 (0.77, 13.43)
Strictly CSOb	0.71 (0.35, 1.43)	0.70 (0.32, 1.49)	1.37 (0.51, 3.72)	2.25 (0.61, 8.35)
Basal Ganglia (BG)c	1.39 (0.72, 2.69)	1.23 (0.53, 2.54)	1.76 (0.61, 5.02)	1.07 (0.24, 4.81)
Mixed CSO-BG scored (score 1 vs 0)	0.75 (0.37, 1.52)	0.72 (0.34, 1.53)	1.64 (0.53, 5.11)	2.46 (0.51, 11.97)
Mixed CSO-BG scored (score 2 vs 0)	1.50 (0.71, 3.16)	1.23 (0.54, 2.82)	3.26 (0.98, 10.81)	2.63 (0.43, 16.13)

ePVS = enlarged perivascular spaces; CSO = centrum semiovale; BG = basal ganglia; CMB = cerebral microbleeds; CI = confidence interval; FHS = Framingham Heart Study;

High burden of enlarged perivascular spaces (ePVS) is defined as grade III or IV (i.e. counts greater than 20). Models adjust for age, sex, FHS cohort, time interval between examination and MRI.

^*p < 0.05

^aIncludes all participants with high CSO burden regardless of BG ratings

^bIncludes participants with exclusively high CSO burden, excluding those who also have high BG ePVS burden

^cIncludes all participants with high BG burden regardless of CSO ratings

^dNumber of CSO-BG regions with high ePVS burden (0=none, 1=one region, or 2=both regions)