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. Author manuscript; available in PMC: 2023 Jun 8.
Published in final edited form as: Circ Cardiovasc Imaging. 2022 Jun 8;15(6):e013987. doi: 10.1161/CIRCIMAGING.122.013987

Table 2:

Comparison between global MBF and MFR estimates obtained with 99mTc-sestamibi SPECT and 13N-ammonia PET with and without spline fitting

Standard OSEM reconstruction
99mTc-sestamibi
SPECT
(N=30)		 13N-ammonia
(N=30)		 p-value
Global rest flow (mL/g/min) 0.80 (0.57-1.07) 0.73 (0.62-0.83) 0.17
Global corrected rest flow (mL/g/min) 0.85 (0.73-0.95) 0.93 (0.70-1.04) 0.84
Global stress flow (mL/g/min) 1.74 (1.22-2.48) 1.45 (1.22-1.67) 0.017
Global MFR 2.15 (1.69-2.94) 1.90 (1.68-2.21) 0.082
Corrected global MFR 2.05 (1.54-2.54) 1.66 (1.26-2.07) 0.012
Rest CVR (mL/min/g/mmHg) 123.1 (103.5-161.7) 115.0 (105.9-141.1) 0.11
Stress CVR (mL/min/g/mmHg) 52.3 (40.7-81.8) 63.9 (51.0-79.7) 0.34
Spline fitting reconstruction
99mTc-sestamibi
SPECT
(N=21)		 13N-ammonia
(N=21)		 p-value
Global rest flow (mL/g/min) 0.58 (0.47-0.71) 0.73 (0.60-0.83) 0.003
Global corrected rest flow (mL/g/min) 0.69 (0.56-0.74) 0.96 (0.68-1.06) 0.001
Global stress flow (mL/g/min) 1.28 (0.88-1.50) 1.44 (1.21-1.80) 0.024
Global MFR 2.20 (1.61-2.46) 1.90 (1.71-2.23) 0.4
Corrected global MFR 1.72 (1.50-2.44) 1.55 (1.22-2.08) 0.073
Rest CVR (mL/min/g/mmHg) 175.7 (133.0-203.1) 117.8 (102.1-151.3) <0.001
Stress CVR (mL/min/g/mmHg) 80.2 (62.2-94.03) 62.6 (50.4-84.4) 0.002

Myocardial blood flow (MBF) is reported in mL/min/g. Myocardial flow reserve (MFR) was calculated as the ratio between stress MBF and that at rest. Coronary vascular resistance (CVR) was calculated as the ratio between mean arterial blood pressure and MBF, and reported as mmHg/ml/min/g.

*

P-values refer to the comparison between SPECT and PET groups and are based on the Wilcoxon signed-rank test.

SPECT: single photon emission computed tomography; PET: positron emission tomography