Table 3:

Analyses of reproducibility for global MBF and MFR

Standard OSEM reconstruction (N=12)
	1st SPECT	2nd SPECT	p-value	Mean difference between paired SPECT scans	Mean percentage difference (%)
Global rest flow (mL/min/g)	0.85 (0.52-1.07)	0.70 (0.56-1.04)	0.76	0.048±0.36	3.1%
Corrected rest flow (mL/min/g)	0.89 (0.73-1.29)	0.89 (0.68-1.42)	0.75	0.054±0.48	5.0%
Stress flow (mL/min/g)	1.65 (1.03-2.69)	1.61 (1.19-2.04)	0.81	0.028±0.63	2.6%
Global MFR	2.19 (1.59-2.48)	2.08 (1.78-2.59)	0.84	0.01±0.76	0.7%
Corrected global MFR	1.60 (1.19-2.46)	1.98 (1.22-2.47)	1.00	−0.04±0.87	2.6%
Spline fitting reconstruction (N=14)
	1st SPECT	2nd SPECT	p- value	Mean difference between paired SPECT scans	Mean percentage difference (%)
Global rest flow (mL/min/g)	0.64 (0.51-0.80)	0.62 (0.54-0.86)	0.46	−0.029±0.17	4.6%
Corrected rest flow (mL/min/g)	0.71 (0.68-0.82)	0.74 (0.64-0.88)	0.14	−0.057±0.19	6.6%
Stress flow (mL/min/g)	1.52 (1.02-1.73)	1.13 (1.00-1.95)	0.73	0.014±0.42	1.4%
Global MFR	2.21 (1.76-2.46)	1.83 (1.71-2.40)	0.51	0.12±0.73	5.6%
Corrected global MFR	1.73 (1.40-2.39)	1.65 (1.36-2.12)	0.59	0.14±0.52	7.6%

Myocardial flow reserve (MFR) is calculated as the ratio between stress myocardial blood flow (MBF) and that at rest.

^*P-values refer to the comparison between two paired SPECT scans performed within 2 weeks and are based on the Wilcoxon signed-rank test. Mean percentage difference (%) was calculated as absolute change in value divided by the average of the two sequential SPECT measurements, multiplied by 100.

SPECT: single photon emission computed tomgraphy.