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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: ChemMedChem. 2022 May 9;17(12):e202200161. doi: 10.1002/cmdc.202200161

Table 1.

Literature 4-anilinoquin(az)oline PKN3 results.

Compound PKN3 IC50 (μM)a
Cabozantinib 42
Sapitinib (AZD8931) 44
Gefitinib 23
Lapatinib 5.9
Vandetanib 0.54
Tesevatinib (XL-647) 0.24
a

IC50 values generated in SLCA assay (n=2).[27-29]