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. Author manuscript; available in PMC: 2023 Jun 20.
Published in final edited form as: ChemMedChem. 2022 May 9;17(12):e202200161. doi: 10.1002/cmdc.202200161

Table 4.

Results of simplified lapatinib analogues 27-34 on PKN3.

graphic file with name nihms-1809638-t0010.jpg
Cmpd X R1 R2 R3 R4 PKN3a
IC50 (μM)
Lapatinib - - - - - 5.9
32 CH OCH3 OCH3 Cl A 8.2
33 N OCH3 OCH3 Cl A 17
34 CH OCH3 OCH3 OH B 38
35 CH OCH3 OCH3 OH C >50
36 CH OCH3 OCH3 H D >50
37 CH OCH3 OCH3 H E >50
38 CH OCH3 H OH B >50
39 CH H OCH3 OH B 11
a

IC50 values generated in SLCA assay (n=2).[27-29]