Table 2:
Comparative characteristics of patients with B-cell ALL and T-cell ALL treated in Total 11, 12, 13A, 13B, 14, 15, and 16 Studies at St Jude Children’s Research Hospital, 1984–2017
| Number of patients (%) | p value | ||
|---|---|---|---|
| B-cell ALL (n=1302) | T-cell ALL (n=257) | ||
| Age, years | ·· | ·· | p<0·0001 |
| <1 | 27 (2%) | 3 (1%) | ·· |
| 1–9 | 964 (74%) | 142 (55%) | ·· |
| 10–15 | 235 (18%) | 87 (34%) | ·· |
| 16–18 | 76 (6%) | 25 (10%) | ·· |
| Median | 5·10 | 8·92 | ·· |
| Gender | ·· | ·· | p<0·0001 |
| Male | 703 (54%) | 184 (72%) | ·· |
| Female | 599 (46%) | 73 (28%) | ·· |
| Race | ·· | ·· | p<0·0001 |
| White | 1033 (79%) | 181 (70%) | ·· |
| Black | 182 (14%) | 65 (25%) | ·· |
| Others* | 87 (7%) | 11 (4%) | ·· |
| Leucocyte count, ×109/L | ·· | ·· | p<0·0001 |
| <10 | 641 (49%) | 40 (16%) | ·· |
| 10–24 | 274 (21%) | 38 (15%) | ·· |
| 25–49 | 144 (11%) | 28 (11%) | ·· |
| 50–99 | 133 (10%) | 43 (17%) | ·· |
| ≥100 | 110 (8%) | 108 (42%) | ·· |
| Median | 10·13 | 76·40 | ·· |
| Haemoglobin, g/dL | ·· | ·· | p<0·0001 |
| ≤10 | 1028 (79%) | 119 (46%) | ·· |
| >10 | 274 (21%) | 138 (54%) | ·· |
| Median | 7·7 | 10·5 | ·· |
| Platelet count, ×109/L | p=0·0054 | ||
| ≤100 | 903 (69%) | 155 (60%) | ·· |
| >100 | 399 (31%) | 102 (40%) | ·· |
| Median | 52 | 70 | ·· |
| Mediastinal mass | ·· | ·· | p<0·0001 |
| Absent | 1296 (100%)† | 180 (70%) | ·· |
| Present | 6 (<1%) | 77 (30%) | ·· |
| CNS status‡ | ·· | ·· | p<0·0001 |
| CNS1 | 856 (66%) | 127 (49%) | ·· |
| CNS2 | 342 (26%) | 90 (35%) | ·· |
| CNS3 | 29 (2%) | 17 (7%) | ·· |
| Traumatic lumbar puncture with blasts | 74 (6%) | 23 (9%) | ·· |
ALL=acute lymphoblastic leukaemia.
*
Asian, Hispanic, and mixed race.
†
100% due to rounding.
‡
Information not available for one patient with B-cell ALL.