Table 5.

Tumor-associated circular RNAs abnormally expressed in keloid scars

circRNA	circRNA expression	Potential value	Target miRNAs	Main associated tumors	References
circRNA COL5A1	Up-regulated	Promoted proliferation, migration and ECM deposition Inhibited cell apoptosis	miR-7-5p	Renal Cell Carcinoma	[171]
circRNA NRIP1	Up-regulated	Promoted proliferation Increased expression of ECM-associated proteins Suppressed apoptosis	miR-503-3p miR-503-5p	Lung cancer Gastric cancer	[172]
circRNA_0008259	Down-regulated	Inhibited type I and III collagen expression	N/A	Gastric cancer	[174]

miRNA microRNA, circRNA circular RNA, ECM extracellular matrix, N/A not available