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GIPR agonism enhances the anorectic action of PYY. Body weight and food intake in obese mice dosed once daily with an LAPYY analog at 3 nmol/kg (A and B), 10 nmol/kg (C and D), and 300 nmol/kg (E and F) alone or in combination with an LAGIPRA (10 nmol/kg) (n = 6 per group). Values are means ± SEM. *P < 0.05 vs. vehicle; #LAPYY vs. LAGIPRA + LAPYY.
