Figure 3.

GIPR agonism attenuates PYY-induced aversion in mice. Saccharin preference (A and B) and food intake (C and D) and 24 h body weight (E and F) in lean C57/Bl6 mice dosed subcutaneously (SC) with an LAPYY agonist alone (C and D) and in combination (E and F) with a GIPRA dosed peripherally or centrally (intracerebroventricular injection [ICV]) (n = 6–11 per group). Values are means ± SEM. *P < 0.05 vs. vehicle (Veh). Statistical analyses performed included Student unpaired t test or one-way ANOVA, followed by Dunnett multiple comparisons test where appropriate.