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. 2022 Jun 24;22:699. doi: 10.1186/s12885-022-09777-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Kaplan–Meier survival curves of the relapse-free survival for GC-TLS formation in patients with ESCC. A. The group who received neoadjuvant chemotherapy (survival rate at 36 months: 86.7%, and 75.5%, respectively). B. The group without neoadjuvant chemotherapy (survival rate at 36 months: 61.1%, and 45.5%, respectively). C. The group who received neoadjuvant chemotherapy with clinical stage 0, I, and II (survival rate at 36 months: 61.4%, and 55.6%, respectively). D. The group who received neoadjuvant chemotherapy with clinical stage III, IVa (survival rate at 36 months: 37.1%, and 65.0%, respectively). E. Hazard ratios were calculated by grouping patients according to clinical progression (III, IVa and 0, I, II) as forest plots. HR, hazard ratio; p < 0.05, statistically significant