Table II.

Mean colony-forming unit data from Figures 4b to 4e.

Group	Animal number	Bone	Soft-tissue	Cement spacer	Total
Antibiotic-free spacer	1	1.875 × 105	3.54 × 105	1.45 × 105	6.86 × 105
	2	3.75 × 105	2.28 × 105	3.22 × 105	9.25 × 105
	3	3.50 × 105	1.84 × 105	6.43 × 105	1.17 × 106
	4	1.52 × 105	2.08 × 105	4.50 × 105	8.10 × 105
	5	1.80 × 105	6.60 × 105	3.54 × 105	1.19 × 106
	6	5.20 × 105	1.44 × 105	4.38 × 105	1.10 × 106
	7	9.20 × 104	4.96 × 105	2.88 × 105	8.76 × 105
Van-spacer	1	6.55 × 104	2.86 × 104	520	9.46 × 104
	2	2.84 × 104	4.52 × 104	738	7.43 × 104
	3	1.25 × 105	4.36 × 105	86	5.61 × 105
	4	4.34 × 104	3.70 × 104	475	8.08 × 104
	5	1.66 × 104	2.94 × 105	120	3.11 × 105
	6	5.35 × 104	8.60 × 104	323	1.39 × 105
	7	1.84 × 104	1.27 × 105	60	1.45 × 105
IP & Van-spacer	1	24	36	50	110
	2	37	240	26	303
	3	25	127	38	190
	4	38	820	225	1083
	5	50	96	44	190
	6	0	0	0	0
	7	132	54	128	314
IA & Van-spacer	1	0	0	0	0
	2	0	0	0	0
	3	0	0	0	0
	4	0	0	0	0
	5	0	0	0	0
	6	0	0	0	0
	7	0	0	0	0

The four treatment groups: Control (antibiotic-free cement spacer); Van-Cement spacer (4 g vancomycin per 40 g cement powder); IP & Van-Cement spacer (4 g vancomycin per 40 g cement powder, and IP injection of vancomycin, 88 mg/kg, 1 ml, every 12 hours); IA & Van-Cement spacer (4 g vancomycin per 40 g cement powder, and IA injection of vancomycin, 44 mg/kg, 150 µl, once per day); n = 7. The limit of detection of bacteria in the culture results was 0 colony-forming units, and each sample was tested in triplicate repeatedly and averaged.

IA, intra-articular; IP, intraperitoneal; Van, vancomycin.