Figure 1.
The volcano plot shows significant differences in the DNA methylation status of 850K CpG sites between MIS-C and non-MISC using the described experimental and bioinformatic pipeline. Y-axis shows the -log10P-value and X-axis shows the mean methylation difference according to beta value. A total of 33 CpGs with a delta beta >0.15 and FDR adjusted P-value <0.05 are shown in red. For those with an associated coding sequence, the gene name is also indicated. CpG-sites that exhibited a methylation beta value difference <0.15 and/or FDR adjusted P-value >0.05 are shown in grey. Dashed lines indicate cut-offs for significance.