Table 3.
Epigenetic changes in coding genes associated with MIS-C diagnosis.
| Gene symbol | Gene name | Gene function | Adjusted P-value |
|---|---|---|---|
| ADCY3 | Adenylate cyclase 3 | Catalyzes the synthesis of cyclic AMP (cAMP) from ATP. ADCY3 variants have been associated to risk/susceptibility to obesity, diabetes and chronic inflammatory diseases. | <0.001 |
| AIM2 | Absent in melanoma 2 | Assembles the macromolecular inflammasome complex. | <0.001 |
| CUL2 | Cullin 2 | Mediator of inflammation. | 0.0096 |
| CYREN | Cell cycle regulator of NHEJ | Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair. | 0.0136 |
| GPR111 | G Protein-Coupled Receptor 111 | Member of the adhesion G protein-coupled receptors (aGPCRs). | <0.001 |
| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | Encodes a beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. | 0.0421 |
| KIF13A | Kinesin family member 13A | Motor protein that also mediates the trafficking of influenza A virus ribonucleoproteins, and transport of an arenavirus protein. | <0.001 |
| NDST2 | N-deacetylase and N-sulfotransferase 2 | Enzyme with dual functions in processing glucosamine and heparin polymers. | 0.0010 |
| PM20D1 | Peptidase M20 domain containing 1 | Enzyme that regulates the production of N-fatty-acyl amino acids. Considered a metabolic disease-associated gene also linked to neurodegenerative disorders. | 0.0328 |
| RARG | Retinoic acid receptor gamma | Receptor for retinoic acid. Act as transcriptional regulator. | <0.001 |
| SH2D1B | SH2 domain containing 1B | Adaptor protein for the signaling lymphocytic activation molecule family of receptors that enhances immune responses to antigens, including viral proteins such as HIV-Gag. | <0.001 |
| SSUH2 | Ssu-2 homolog | A putative chaperone protein. | 0.0092 |
| VWA8 | Von Willebrand factor A domain-containing protein 8 | Mitochondrial ATPase protein. | <0.001 |
| ZAK | ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase | Mitogen-activated protein kinase, also known as MAP3K20. | <0.001 |
| ZEB2 | Zinc finger E-box binding homeobox 2 | ZEB2 is a DNA-binding transcriptional repressor. | <0.001 |