A, Brain regions with significant differential response to early versus late conditioning trials, for the conditioned inhibitor (AX–early > AX–late) and standard safety signal (BC–early > BC–late). Whole-brain FDR-corrected (p < 0.05) results are displayed on a high-resolution anatomic template in MNI space. B, Minimal overlap observed between the differential response to the early versus late conditioned inhibitor trials (AX–early > AX–late, yellow), and the response to the conditioned threat alone (A+, purple).