Table 1.
Comparing obesity and metabolic dysfunction in altered models of eosinophils
| Strain | Animal model | Eosinophils* | Obesity | Metabolic dysfunction | Ref |
|---|---|---|---|---|---|
| BALB/c | ΔdblGATA | Depleted | Prevents | Worsens | 17 |
| C57BL/6 | ΔdblGATA | Depleted | Worsens | Worsens | 11 |
| Helminth (acute) | Increased above normal | No change | No change | 30 | |
| Helminth (chronic) | Increased above normal | Prevents | Prevents | 14 | |
| Helminth antigen | Increased above normal | Prevents | Prevents | 18 | |
| Honeybee extract | Increased above normal | Prevents | Prevents | 15 | |
| IL-5 transgenic | Increased above normal | Prevents | Prevents | 19 | |
| IL-5 i.p. | Normal | No change | No change | 16 | |
| Eotaxin2 transgenic | Increased adipose eosinophils above normal | Prevents | Prevents | 12 |
Eosinophils are all circulating except in Eoxtaxin2 transgenic as noted.