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. Author manuscript; available in PMC: 2022 Jun 25.
Published in final edited form as: Science. 2022 Apr 1;376(6588):eabl4178. doi: 10.1126/science.abl4178

Fig. 2. Structural rearrangements, genes, and TEs in peri/centromeric regions.

Fig. 2.

(A) The peri/centromeric region of chr1 (cylindrical schematic at top), zooming into the transition region between the large αSat and HSat2 arrays (tracks 1 to 4). Track 1, satellite families (color key at bottom left), with vertical placement indicating the strand with canonical satellite repeat polarity. Track 2, positions of TEs overlapping αSat or HSat1,2,3, colored by TE type. Track 3, annotated transcription start sites, colored by gene type. Track 4, HSat2,3 subfamily assignments [as in (11)] and αSat SF assignments, with large arrays labeled. (B) As in (A) but for chr17, with the previously unresolved HSat3B1 array indicated with an asterisk. (C) Gene annotations between the αSat and HSat3 arrays on chr17. (D) Heatmap showing the major and minor localizations of each αSat HOR SF (top; red) and each HSat2,3 subfamily (bottom; blue). “N” indicates localizations not described in (11). Dash “–” indicates the chr1 HSat3B2 array deleted in CHM13. HSat3A3 and 3A6 are predominantly found on chrY (not in CHM13). (E) Barplots illustrate the number of inversion breakpoints (strand switches) or the number and type of TEs detected per megabase within different satellite families. div, divergent αSat (dHORs + monomeric).