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. 2022 Jun 18;2022:9498876. doi: 10.1155/2022/9498876

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Copyright © 2022 Min Shen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Metformin enhanced osteogenic differentiation capacity of UC-MSCs. (a) Osteogenically differentiated cells were identified with Alizarin Red staining after 21 days incubation. Scar bar = 200 μm (100x). (b) ALP activity of UC-MSCs was evaluated after 7 days incubation. Scar bar = 200 μm (100x). (c–f) Quantitative analysis of osteogenic genes expression by RT-qPCR, including ALP (c), RUNX2 (d), OCN (e), and COL 1A1 (f). n = 3; ^∗∗P < 0.01, ^∗∗∗P < 0.001. (g) Osteogenic proteins of ALP, RUNX2, and OCN were assessed by western blot.