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. 2022 Jun 25;7:199. doi: 10.1038/s41392-022-01056-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — CRISPR-mediated adaptive immunity. Type I-C, type I-E, and type I-F CRISPR-Cas systems have been identified in P. aeruginosa. Type I CRISPR-Cas targeted endogenous LasR gene to decrease TLR4 expression and TLR4-mediated host inflammatory responses. Similarly, type I CRISPR-Cas systems elicited inflammasome activation by promoting mitochondrial-mediated autophagy. Ultimately, CRISPR-mediated adaptive immunity helps P. aeruginosa evade mammalian host immunity