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. 2022 Jun 25;13(6):568. doi: 10.1038/s41419-022-05004-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Control or S100A11-knockdown PDAC cells were transfected with or without ectopic FLAG-tagged TKT and western blot analysis was performed using the indicated antibodies. B–D Control or S100A11-knockdown PDAC cells were transfected with empty or FLAG-tagged TKT plasmid. PPP flux was analysed using NMR. De novo DNA synthesis was analysed using EdU incorporation. Cellular NADPH level was measured in PDAC cells after S100A11 knockdown. E, F In the above cells, the effect of TKT on proliferation and migration was confirmed by colony formation and Transwell assays. n.s., not significant. *p < 0.05. Error bars indicate mean ± SD.