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. 2022 Jun 25;13:3652. doi: 10.1038/s41467-022-31376-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a UMAP overlaying scRNA of Panc1 samples and their unique clusters. b Pathway enrichment profiles defined by GSEA analysis for Panc1-2D and Panc1-3D spheroid cell clusters. Size of dot represents FDR, red indicates upregulation, blue indicates downregulation of the pathway. c UMAP representing snATAC-seq data of merged Panc1 samples. d, e Analysis of merged Panc1 snATAC data shows enrichment in Sp/Klf motifs in spheroid data, and enrichment of Fos/Jun motifs in 2D monolayer culture. f Comparison of expression of genes associated with Sp/Klf transcription factors in scRNA of Panc1 2D and Panc1 3D. g Comparison of expression of genes associated with Fos/Jun transcription factors in scRNA of Panc1 2D and Panc1 3D.