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. 2022 Jan 11;13(10):760–777. doi: 10.1007/s13238-021-00895-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The pseudoatomic model of the CR and NR from the X. laevis oocyte NPC. (A) Overall view of the X. laevis NPC CR and NR structure, displaying the inner and outer Y complexes in each asymmetric unit, as well as the densities other than the Y complexes. (B) Model-map overlay of the NPC CR subunit. The map density is displayed in gray with transparency. Models of the inner Y complex, outer Y complex and extra densities are in the same colors as in (A). (C) Model-map overlay of the NPC NR subunit. The map density is displayed in gray with transparency. Models of the inner Y complex, outer Y complex and extra densities are in the same colors as in (A). (D) Model display of two Y complexes in the NR subunit. All Nups are colored differently and labeled. The major differences compared with the previous 2015-model are highlighted in the transparent gray surface. Nup107 region and Y complex hub regions are shown in zoomed-in views. The 4th zoomed-in view is rotated for better display. Important regions are labeled with the sequence and secondary structure numbers