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. 2022 May 28;117(6):1464–1478. doi: 10.1111/mmi.14921

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© 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The impact of peptides on pneumococcal growth in CDM supplemented with mannose. (a) Growth profiles of pneumococcal strains in CDM containing 55 mM mannose. (b) Exogenous addition of wild type C13 peptide (but not mutant peptides) restores mutant shp144 growth on mannose. Comparisons are made relative to Δshp144 culture without peptide. (c) Inhibition of growth of wild type Streptococcus pneumoniae on mannose by SHP P21A. Error bars show the standard error of the mean from at least three independent experiments. *p < .05, **p < .01, ****p < .0001.