Table 1.

The role of EC-derived EVs in tumor and non-tumor diseases

		Parent cell	Biological function	Reference
EVs on tumor cells
NcRNA	miR-503	HUVECs	Inhibits cancer proliferation and invasion	[46]
	miR-126	HUVECs	Inhibits the growth of tumor cells	[47]
	MALAT1	HUVEC	Promotes invasion in HCC	[48]
Protein	S100A16	HBMECs	Promotes SCLC survival in brain	[49]
	Dll4	HMVECs	Promotes angiogenesis	[50]
	Ang2	Primary mouse lung endothelial cells	Promotes tumor growth	[51]
	CEACAM1	human endothelial cell line AS-M.5	Modulate immune response, tumor progression, metastasis and angiogenesis	[52]
EVs on non-neoplastic diseases
NcRNA	miR-10b-5p	HUVEC	Reduced inflammation in cardiovascular disease	[59]
	miR-125a	Human lung microvascular	Modulate the phenotype of distant endothelial cells of large systemic	[53]
	miR-143	HUVEC	Control smooth muscle cell phenotype	[62]
	miR-146a	HUVEC	Decrease in metabolic activity in peripartum cardiomyopathy	[60]
	miR-191	Human lung microvascular	Predicting potential function of exosomes as paracrine effectors in COPD	[53]
	miR-210	Endothelial progenitor cells	Protective effects on ECs against H/R injury	[54]
	miR-375	Endothelial progenitor cell	Rescued the cell protection activity	[55]
	miR-214	HMEC-1	Blood vessel formation	[56]
	miR-505	HUVEC	Inducing Oxidative stress and inflammation in atherosclerosis	[64]
	miR-155	HUVEC	Modulate the macrophage phenotype in atherosclerosis	[65]
	miR-19a	HUVEC	Improved vascularization and cardiac function, decreased myocardial fibrosis	[61]
Protein	TGF-β1	Glomerular endothelial cells	Ameliorate renal structure and function	[66]
	Versican	HUVEC	Regulate vascular smooth muscle cells calcification/senescence in high glucose condition	[63]
	LOXL2	Human microvascular endothelial cells	Altered abundances after exposure of their producing cells to cellular stress	[57]
	Cytomegalovirus	HUVEC	Stimulate allogeneic CD4 + Memory T Cells	[67]
	HSP70	Rat aortic endothelial cells	Induction of monocyte activation and endothelial cell adhesion	[58]