Table 1.
Genotypes | (D2-D5) × ( D6-D10) | (D2-D5) × (D11-D15) | (D2-D5) × (D16-D20) | (D2-D5) × (D21+++) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | |
RR vs. SS | 10 | 1.62–3.22 | 0.002* | 43.54 | 2.97–8.5 | < 0.0001* | 55 | 3.43–11.93 | < 0.0001* | 687.5 | 7.41–362 | < 0.0001* |
RR vs. RS | 4.55 | 1.14–1.98 | 0.07 | 6.71 | 1.24–1.91 | 0.01* | 5.19 | 1.15–1.7 | 0.03* | 6.83 | 1.2–1.7 | 0.008* |
RS vs. SS | 2.19 | 1.09–2.09 | 0.008* | 6.48 | 1.90–5.60 | < 0.0001* | 10.58 | 2.42–8.39 | < 0.0001* | 100.60 | 5.16–253 | < 0.0001* |
R vs. S | 2.02 | 1.06–1.82 | 0.02* | 4.19 | 1.48–2.59 | < 0.0001* | 3.71 | 1.40–2.43 | < 0.0001* | 5.1 | 1.62–2.93 | < 0.0001* |
CI Confidence interval, D day (post-exposure), CYP6P9a–RR homozygous resistant, CYP6P9a–RS heterozygous resistant; CYP6P9a–SS homozygous susceptible, OR odds ratio
*Indicates significant difference between genotypes for the OR