Skip to main content
NCBI home page
Age and Ageing logoLink to Age and Ageing
. 2022 Jun 26;51(6):afac151. doi: 10.1093/ageing/afac151

Effectiveness of integrating primary healthcare in aftercare for older patients after discharge from tertiary hospitals—a systematic review and meta-analysis

Ran Li 1,2, Jiawei Geng 3, Jibin Liu 4, Gaoren Wang 5, Therese Hesketh 6,7,✉
PMCID: PMC9233979  PMID: 35753767

Abstract

Background

Quality of aftercare can crucially impact health status of older patients and reduce the extra burden of unplanned healthcare resource utilisation. However, evidence of effectiveness of primary healthcare in supporting aftercare, especially for older patients after discharge are limited.

Methods

We searched for English articles of randomised controlled trials published between January 2000 and March 2022. All-cause hospital readmission rate and length of hospital stay were pooled using a random-effects model. Subgroup analyses were conducted to identify the relationship between intervention characteristics and the effectiveness on all-cause hospital readmission rate.

Results

A total of 30 studies with 11,693 older patients were included in the review. Compared with patients in the control group, patients in the intervention group had 32% less risk of hospital readmission within 30 days (RR = 0.68, P < 0.001, 95%CI: 0.56–0.84), and 17% within 6 months (RR = 0.83, P < 0.001, 95%CI: 0.75–0.92). According to the subgroup analysis, continuity of involvement of primary healthcare in aftercare had significant effect with hospital readmission rates (P < 0.001). Economic evaluations from included studies suggested that aftercare intervention was cost-effective due to the reduction in hospital readmission rate and risk of further complications.

Conclusion

Integrating primary healthcare into aftercare was designed not only to improve the immediate transition that older patients faced but also to provide them with knowledge and skills to manage future health problems. There is a pressing need to introduce interventions at the primary healthcare level to support long-term care.

Keywords: systematic review, long-term care, primary health, discharge, older people, aftercare

Key Points

  • Continuity of involvement of primary healthcare in aftercare had significant interaction with hospital readmission rates.

  • Integrating primary health into aftercare can provide patients with knowledge and skills that could be applied to the future.

  • Aftercare intervention was cost-effective due to the reduction of hospital readmission rate and risks of further complications.

  • There is a current shift away from interventions stressing human interactions towards those with more technological interaction.

Introduction

Worldwide, the number of people aged 65 or older is projected to increase from 750 million in 2020 to approximately 1.5 billion in 2050 [1]. Older patients are the most frequent users of healthcare services globally, accounting for over half of all hospital admissions [2]. Economists from the UK estimated that appropriate discharge plans for older patients could save up to 1 million days of hospitalisation and about US$1 billion in costs of readmission [3, 4].

The use of primary healthcare to provide transitional aftercare for older adults has been increasing in many countries [5, 6]. Primary healthcare can provide an entry point into the health system, ongoing care coordination and a person-focused approach for patients and their families [7]. In 2000 a new vision of primary healthcare was developed by the WHO as a foundation of universal health coverage. It focuses on integrated healthcare, multisectoral approaches and community engagement in health [8].

The WHO reports that continuity of care is a key element in quality of aftercare [9]. Continuity of care by primary healthcare providers can be categorised as follows: (i) interpersonal continuity: trusting relationships between primary healthcare providers, patients and caregivers; (ii) longitudinal continuity: a history of interaction with the same primary healthcare providers in a series of discrete periods; (iii) management continuity: entailing effective cooperation of different teams across care boundaries to offer seamless healthcare and (iv) informational continuity: availability of clinical and psychosocial information to primary healthcare providers [10].

We know of no existing reviews examining the effectiveness of using primary healthcare as transitional and integrated aftercare for older patients after discharge. Therefore, this study aimed to explore the relationship between integration of primary healthcare in transitional aftercare, and outcomes of healthcare utilisation, patients’ health-related quality of life (HRQOL), with the following objectives:

  • To identify the effective characteristics of the integration of primary healthcare into transitional aftercare for older patients.

  • To determine whether integration of primary healthcare into transitional aftercare reduces healthcare resource utilisation and improves health status of patients after discharge.

  • To analyse the costs of integrated primary healthcare aftercare for older patients.

Method

Study design

This systematic review and meta-analysis were conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline [11]. The protocol for this study was registered in PROSPERO (CRD42021242917).

Search strategy

We searched for full-text articles in English published between January 2000 and 31 March 2022 using the following electronic databases: EMBASE, PubMed, Web of Science, Cochrane, CINAHL, PsycInfo and Google Scholar. The references of the relevant articles and reviews were manually checked to identify additional studies. Key search terms were: older adults, patients discharge, primary healthcare and aftercare. Full search strategies in PubMed are available in Appendix 1. Endnote (X8.0, Clarivate Analytics) was used to manage all search results.

Eligibility criteria

Only peer-reviewed randomised control trials (RCTs) were eligible. Inclusion criteria were studies which involved: (i) patients aged 65 or over; (ii) patients hospitalised for chronic diseases for more than one day with aftercare needs; (iii) interventions describing at least one component that aimed to improve the continuity of care between hospital and primary healthcare facilities and (iv) reported outcomes including any of the following: length of hospital stay, hospital readmission rate, and HRQOL. Studies were excluded if: (i) patients had any mental disorder, including cognitive impairment or dementia and (ii) pilot studies, study protocols and studies with only abstracts.

Study selection

Three researchers in parallel screened and selected studies (RL, JWG and JBL). RL and JWG independently screened each reference title and abstract for relevance to this review. RL and JWG evaluated these articles against the eligibility criteria. Controversial issues were discussed among the three researchers.

Data synthesis and analysis

Data extraction was conducted by three investigators individually and cross-checked. A narrative review of intervention characteristics from individual studies was presented. We classified the intervention components, associated with continuity of care between hospitals and primary healthcare facilities, into four elements according to the WHO’s guideline mentioned above.

The primary outcome of this review was all-cause hospital readmission rate, stratified by time to within 1 month and within 6 months after discharge from hospital. The secondary outcomes were length of hospital stay, HRQOL and costs of aftercare. R (V4.0.3) was used to perform the meta-analyses and subgroup analyses. The effect size was defined as the standard mean differences (SMDs) in length of hospital stay and the risk ratio (RR) of the hospital readmission rate, between intervention and control groups. A random-effects model was utilised to generate pooled estimates of the overall effects and reported 95% confidence intervals with all measures of effect. Both Inline graphic tests (Cochran’s Q) and Inline graphic statistics were used to examine heterogeneity across studies (Ι2 values of 25, 50 and 70% were defined as low, moderate and high level of heterogeneity, respectively). Owing to large differences in assessment methods, we have also presented a narrative review of the results of patients’ HRQOL and costs.

We specified subgroups in advance to further identify the relationship between intervention characteristics and the effect on hospital readmission rate controlling for: (i) frequency of follow-up (less or equal to once per month or more than once per month); (ii) discharge coordinators (no more than two professionals or multidisciplinary team) and (iii) intervention components regarding continuity of care between hospitals and primary healthcare providers (single or multifaceted). A leave-one-out sensitivity analysis was performed to assess the robustness of the results.

Quality assessment

Included studies were appraised to assess the risk of bias for methodological quality. The assessment of risk of bias was performed according to guidance in the Cochrane Collaboration’s Risk of Bias handbook for RCTs [12]. The risk level in this review was classified as ‘high’, ‘low’ or ‘unclear’. Features of the process of the randomisation, allocation concealment, blinding of participants and outcome assessors, incomplete outcome and selective reporting were assessed. If more than ten articles were included in the meta-analysis, funnel plots were conducted to detect publication bias. Besides visual inspection, Egger and Begg tests were conducted to adjust potential effect of publication bias on results interpretation.

Results

Search results

We identified 16,214 articles from the seven databases. A total of 744 articles were found for full text reviewing. Of these, 720 were eliminated against eligibility criteria. An additional six articles were found from references of relevant reviews, yielding a total of 30 studies. All 30 studies were involved in qualitative synthesis. Of these 25 studies providing data on length of hospital stay and readmission rate were included in the meta-analysis. A flow diagram of the selected studies is shown in Figure 1.

Figure 1.

Figure 1

Open in a new tab

Flow diagram of study selection.

Study characteristics

These studies were all prospective RCTs published between 2001 and 2020, with 17 published after 2010. All studies were conducted in high income countries or regions, and in urban settings. Seven studies were from Australia [13–19]; six from the United Kingdom [20–25]; five from the United States [26–30]; two each from Canada [31, 32], Norway [33, 34] and Spain [11, 35]; and one each from Denmark [36], Hong Kong (China) [37], France [38], Italy [39], New Zealand [40] and Switzerland [41] (Appendix 2).

The 30 studies involved 11,693 participants in total. The mean sample size was 390, ranging from 42 to 2,494. The mean age range of patients across the 30 articles was 70 to 84 years. The duration of the trials ranged from one to 18 months. Half of the interventions lasted for less than 6 months [16, 17, 19–24, 28, 29, 34, 36, 37, 39, 40]. A total of 28 studies used treatment-as-usual, and standard procedures for discharge and aftercare, as a control [13–20, 22–41].

The 30 studies differed in their overall objectives, including (i) improving quality of aftercare [14, 17, 19–25, 29, 33, 34, 36–38, 42], (ii) facilitating coordination between hospitals and primary healthcare providers [13, 25, 26, 32, 34], (iii) increasing patients’ self-management ability [30, 35, 41], (iv) enhancing medication adherence [16, 26], (v) saving costs of aftercare and healthcare services following discharge [23, 27] and (vi) reducing inappropriate healthcare resource utilisation [15, 18, 24, 28, 31, 39, 40].

Intervention characteristics

Every intervention was multicomponent, using a comprehensive program, model, protocol or bundle with a range of specific activities and tools. Characteristics of the 30 studies are described in Appendix 2.

The interventions were applied in one or more stages of pre-discharge, at discharge and post-discharge. All 30 studies focused on aftercare post-discharge: ten of them additionally applied interventions on handover support at discharge [17, 18, 23, 25, 29, 31, 33, 35, 38, 40]. Four studies conducted discharge preparedness activities during hospitalisation, in addition to aftercare [16, 19, 37, 41]. Finally, 11 studies focused on the whole process of the three stages mentioned above [13, 14, 17, 18, 20, 23, 25, 27, 28, 35, 40]. Appendix 3 provides a descriptive overview of activities in different stages of discharge in each study.

Components of engagement of primary healthcare

All of the included studies involved primary healthcare during the process of continuity of care. The major component is longitudinal continuity. Nine studies mentioned that the follow-up after discharge was provided by GPs [13, 16, 23–25, 28, 32, 33, 36, 39, 40]. Other primary healthcare providers included community pharmacists [17, 21, 23, 35], physiotherapists [18, 19, 21], primary care nurse practitioners [14–16, 18, 19, 21, 22, 26–28, 30–32, 34, 36, 37, 40–42] and allied health professionals [35, 42].

Regarding information continuity, ten studies conducted information exchange between primary healthcare providers and other professionals at discharge and aftercare [13, 15, 20, 22, 27, 29, 30, 33, 35, 41]. The information exchange consisted of database-generated discharge summaries and online reference information about rehabilitation. In addition, 10 of the 30 studies explicitly described the components of communication between primary healthcare providers and other healthcare professionals [13, 16, 17, 20, 27, 31, 33, 40, 42]. Relevant activities were face-to-face meetings regarding issues of aftercare and patients’ health status and timely conversation through telephone, fax or emails to transmit discharge plans.

Management continuity was predominantly performed by care coordination in 20 studies [13, 14, 16, 17, 20, 22, 24, 26–31, 33, 36–38, 40–42]. Joint follow-up between hospital nurses and primary healthcare providers was the main activity. All but three studies involved more than two professionals as multidisciplinary teams [35–37]. Two studies implemented mobile health interventions for aftercare and follow-up [29, 33]. They generated patients’ daily health records after hospitalisation and provided feedback from healthcare professionals accordingly, through smart phone.

Additionally, three studies tested the consistency between GPs’ knowledge of patients’ health experience and the subjective experience of patients themselves to assess interpersonal continuity [15, 29, 33]. Half of the included studies comprised more than one component of engagement of primary healthcare [13, 15–17, 20, 22, 23, 27, 28, 32, 33, 37, 41, 42].

Discharge destination and follow-up frequency

The most common discharge destination is home [13–16, 18–22, 24–28, 30–32, 35–37, 40, 41], followed by nursing home [17, 23, 29, 34]. For four studies, patients were discharged to a step-down facility, either geriatric hospitals or nursing home, and then home [33, 38, 39, 42].

For all studies, follow-up was initiated within the first week after hospital discharge. Most of the studies provided follow-up at a fixed interval with frequency varying considerably. For eight studies, follow-up was provided weekly [15, 18, 21, 30–32, 34, 39] with reduction in frequency over time. Five studies stated that the frequency of follow-up was tailored to the needs of patients [22, 26, 38, 39, 41]. All studies provided contact information of personnel for patients to contact at any time.

Outcome measures

Among the total 30 studies, 25 were included in the meta-analysis [14–23, 25, 27–33, 35–40, 42]. Nineteen of them reported hospital re-admission rates [14, 15, 18–22, 27, 28, 30–33, 36–39, 42]; 15 reported length of hospital stay [15–17, 21–23, 25, 29–31, 35, 38–40]. In addition, 20 studies assessed HRQOL [13–25, 28, 31–33, 35, 37, 42], and 13 studies conducted economic evaluation [13, 17, 19, 26–30, 35, 36, 39–41].

Meta-analysis of hospital readmission rates and length of hospital stay

As shown in Figure 2, the pooled relative risk shows that patients in the intervention group had 32% less risk of hospital readmission within 30 days than patients in the control group (RR = 0.68, P < 0.001, 95%CI: 0.56–0.84), with moderate heterogeneity (I2 = 67%, Inline graphic2 = 39.84, P = 0.01). Patients in the intervention group were 17% less likely to be readmitted to hospital within 6-month period compared to those in the control group (RR = 0.83, P < 0.001, 95%CI: 0.75–0.92) (Figure 3). Heterogeneity was moderate (I2 = 59%, Inline graphic=36.53, P = 0.01). Further sensitivity analyses revealed no substantial difference in the overall effect for 30-day and 6-month hospital readmission rate.

Figure 2.

Figure 2

Open in a new tab

Results of 30-day hospital readmission.

Figure 3.

Figure 3

Open in a new tab

Results of within 6-month hospital readmission.

Subgroup analyses (Appendix 4) were consistent with the main findings, showing significant effectiveness in both 30-day and 6-month hospital readmission in the intervention groups. Interventions containing multifaceted components of continuity of care [28, 31–33, 36–38, 42] were associated with stronger effectiveness in within 30-day and within 6-month readmission (RR 0.55, 95%CI: 0.45–0.68; RR 0.73, 95%CI: 0.64–0.83, respectively), compared with interventions with only one component [14, 15, 18–20, 27, 30, 35, 39] (RR 0.88, 95%CI: 0.73–1.06; RR 0.96, 95%CI: 0.90–1.02, respectively).

Trials conducted by multidisciplinary teams [14, 15, 18–20, 27, 28, 30–32, 37–39, 42], and with a frequency of follow-up once per month [15, 18, 20, 28, 30, 32, 33, 37–39] showed a larger overall effect on both 30-day and 6-month readmission, compared with interventions conducted by no more than two professionals [33, 35, 36], and with a high-intensity follow-up [14, 19, 27, 31, 35, 36, 42]. These characteristics of the interventions had no significant interaction with effectiveness.

Patients in the intervention group had a marginal reduction in hospital length of stay compared to controls (SMD = –0.01, 95%CI: −0.12 to 0.10, P = 0.9), with moderate heterogeneity (I2 = 54%, χ2 = 28.34, P = 0.01; Figure 4). No substantial difference in the overall length of hospital stay was revealed in sensitivity analysis.

Figure 4.

Figure 4

Open in a new tab

Result of length of hospital stays.

Patients’ HRQOL and economic evaluation

Among all 20 studies which measured HRQOL, 13 studies reported statistically significant improvement in patients’ HRQOL [15, 16, 18, 21, 22, 24, 25, 28, 32, 33, 35, 42], especially more positive effects on physical status than mental status.

Eleven studies conducted cost-saving analyses [13, 17, 19, 28–30, 35, 36, 39–41]. Of these, seven studies found the cost of the interventions was lower than the control [19, 26, 27, 29, 30, 39, 40]. The main costs were from aftercare services, medical equipment, medications and staff costs. Three studies conducted cost–benefit analysis [26, 27, 41]. All of them suggested that aftercare intervention provided considerable cost–benefits due to the reduction of hospital readmission rate and risks of further complications. However, they emphasised the importance of larger sample size and more precise record of cost estimates of subsequent rehospitalisation and utilisation of healthcare.

Quality assessment

No study was absolutely free of bias (Appendix 5). Nine studies were assessed as high risk for selection bias [14, 18, 21, 23, 24, 29, 33, 34, 36, 38], as outcome assessors were unblinded to the allocation. Risk of attrition bias was high in 13 studies, as they reported that less than 5% of participants withdrew from the follow-up and analyses were carried-out on an intention-to-treat basis [13, 18, 20, 21, 24, 28, 31, 34, 36–38, 40, 42]. Pre-specified outcomes were missing in one article leading to high reporting bias [31]. The funnel plot of the comparison of 30-day and 6-month readmission rates suggests no significant publication bias.

Discussion

Summary of principle findings

In this systematic review, we included a total of 30 RCTs with 11,693 older patients with aftercare needs. Transitional aftercare interventions were found to cause a significant reduction in 30-day and 6-month hospital readmission rates by 32% and 28%, respectively, compared with the standard discharge process. Economic evaluations in all the studies suggested that transitional and aftercare interventions were cost-effective considering the overall reduction in unplanned use of healthcare resources.

Transitional care intervention design

Subgroup meta-analysis revealed that interventions using a complex and supportive strategy for the continuity of care contributed to stronger effects on quality of aftercare and healthcare resource use. Documented efficacy components of continuity of care interventions include multidisciplinary team of coordination, shared involvement by hospital and primary healthcare providers, timely follow-up, among others [5, 10]. Hesselink et al. [43] also found that comprehensive aftercare intervention with higher quality of handover among multidisciplinary teams is positively correlated with improved HRQOL.

Regarding the effects of varying follow-up frequency, interventions with no more than one follow-up per month had better effects in hospital readmission rates than interventions with higher frequency. Leppin et al. [44] reported that interventions with intensive frequency of follow-up could be beneficial. However, the experience of follow-up is not constant between individual and quality of services provided by different healthcare facilities are different [45]. Therefore, the relationship between intensity of follow-up and patients’ health-related outcomes is inconsistent and of limited applicability.

The secular trend of intervention designs detected in this review were as follows: (i) in recent studies, transitional aftercare interventions have moved from largely depending on the services provided by health professionals, to improving patients’ and caregivers’ ability to self-manage after discharge; (ii) studies published recently showed a higher follow-up frequency following discharge, compared with studies published before 2010 and (iii) there is a current shift away from interventions stressing human interactions towards those with more technological interaction.

Strengths and limitations of this review

To our knowledge, this is the first systematic review to analyse the relationship between the characteristics of continuity of primary healthcare involvement in aftercare, hospital utilisation and patients’ HRQOL, using both meta-analysis and qualitative synthesis. Importantly, this study categorised the activities of interventions by different stages during aftercare to ensure appropriate characterisation of each intervention. Also, this review adds to a body of knowledge analysing integration of primary healthcare in transitional care according to the WHO’s framework of continuity and coordination of care. These methods can be applied to future assessments of complex interventions.

Regarding limitations of this review, self-report was commonly used in most of the included studies. This may of course lead to reporting bias [46]. Though most of the studies reported a calculated sample size for the study and conducted intention-to-treatment analysis, reluctance to be discharged or transferred was reported in five studies [16, 23, 25, 28, 29]. Reasons for the drop-out were as follows: (i) older patients were too ill to be transferred from the hospital; (ii) anxiety about returning home to cope with lingering physical and mental symptoms; (iii) the appointed step-down facilities were located far from the patients’ caregivers.

The duration of the 30 interventions was relatively short, with only eight studies lasting for over 1 year [13, 25, 35, 41]. Short-term effects of interventions are primarily affected by the discharge process, while results after a longer intervention period are more likely to be due to events related to the quality of aftercare [47]. The inconsistent performance of managing discharge across different hospitals and different stage of aftercare may have influenced the precision of results.

Implications for policy and further research

In this systematic review, we found value in interventions where follow-up was conducted by a named primary healthcare professional who had information on a patient’s previous clinical history [13, 16, 23–25, 28, 32, 33, 36, 39, 40]. This activity increased the willingness to be discharged and reduced readmission rates. As a part of longitudinal continuity of care, a positive and continuing relationship with primary healthcare providers enables details of a patient’s medical history to contribute to continuity of care [48].

The ageing population has dramatically increased the burden of chronic diseases, and the proportion and the number of older patients requiring long-term care have increased in countries at all levels of development [49]. Therefore, evidence of integrating primary healthcare into aftercare is very important for delivering appropriate and cost-effective healthcare for older adults.

In addition, a number of studies show that interventions relate to reimbursement structure and lack financial compensation for providing transitional aftercare. Therefore, long-term economic evaluations with larger sample sizes are needed. In particular, one study in this review conducted the intervention in a private hospital. There is a need to analyse the effectiveness of this model in both public and private settings in the future.

Developing new models can introduce new risks of safety for integrating primary healthcare into aftercare, which need to be proactively identified [50]. Evidence from Rytter et al. [36] suggested that timely and close communication and coordination with primary healthcare providers and other professionals are an important solution to enhancing safety. Effective interventions need to be implemented following robust guidelines to ensure the quality of primary healthcare providers’ services.

Conclusion

Transitional aftercare using primary healthcare was designed not only to improve the immediate transitions that older patients faced but also to provide them with knowledge and skills that could be applied to future health. Continuity of primary healthcare involvement in aftercare could be valuable for older adults’ needs after discharge from acute care facilities and in reducing the burden of unplanned hospital utilisation.

Supplementary Material

aa-22-0066-File002_afac151
Click here for additional data file. (53.5KB, docx)

Acknowledgement

The authors draw inspirations from practical cases of Nantong Hanyao Traditional Chinese Medicine Hospital. We would like to thank Ranghao Bao for his proofreading and spiritual support.

Contributor Information

Ran Li, Center of Global Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China; Institute of Global Health, University College London, London, UK.

Jiawei Geng, Center of Global Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China.

Jibin Liu, Department of radiotherapy, Affiliated Tumour Hospital of Nantong University, Nantong, China.

Gaoren Wang, Institute of oncology, Affiliated Tumour Hospital of Nantong University, Nantong, China.

Therese Hesketh, Center of Global Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China; Institute of Global Health, University College London, London, UK.

Declaration of Conflicts of Interest

None.

Declaration of Sources of Funding

This study was funded by the National Natural Science Foundation of China (No. 72150710552). The funding agency had no role in the design of the study; in the collection, analysis or interpretation of the data; or in the writing, approval of the manuscript or decision to submit the manuscript for publication.

References

  • 1. United Nations . World Population Ageing 2019. 2020. https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf (24 April 2022, date last accessed).
  • 2. Vos T, Lim SS, Abbafati Cet al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet 2020; 396: 1204–22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. World Health Organization . Global Health and Aging 2011. https://www.nia.nih.gov/sites/default/files/2017-06/global_health_aging.pdf(24 April 2022, date last accessed).
  • 4. Age UK. Briefing: Health and Care of Older People in England 2019. 2019. https://www.ageuk.org.uk/globalassets/age-uk/documents/reports-and-publications/reports-and-briefings/health--wellbeing/age_uk_briefing_state_of_health_and_care_of_older_people_july2019.pdf (24 April 2022, date last accessed).
  • 5. Braet A, Weltens C, Sermeus W. Effectiveness of discharge interventions from hospital to home on hospital readmissions: a systematic review. JBI Database Syst Rev Implement Rep 2016; 14: 106–73. [DOI] [PubMed] [Google Scholar]
  • 6. Nekhlyudov L, O'Malley DM, Hudson SV. Integrating primary care providers in the care of cancer survivors: gaps in evidence and future opportunities. Lancet Oncol 2017; 18: e30–8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. World Health Organization . Integrated care for older people: Guidelines on community-level interventions to manage declines in intrinsic capacity. 2017. https://apps.who.int/iris/bitstream/handle/10665/258981/9789241550109-eng.pdf?sequence=1&isAllowed=y (24 April 2022, date last accessed). [PubMed]
  • 8. World Health Organization . A vision for primary health care in the 21st: towards universal health coverage and the sustainable development. 2019. https://apps.who.int/iris/bitstream/handle/10665/328065/WHO-HIS-SDS-2018.15-eng.pdf?sequence=1&isAllowed=y (24 April 2022, date last accessed).
  • 9. World Health Organization . Transitions of Care. Technical Series on Safer Primary Care. 2016. https://apps.who.int/iris/bitstream/handle/10665/252272/9789241511599-eng.pdf (24 April 2022, date last accessed).
  • 10. World Health Organization . Continuity and coordination of care: a practice brief to support implementation of the WHO framework on integrated people-centred health services. 2018. https://apps.who.int/iris/bitstream/handle/10665/274628/9789241514033-eng.pdf?sequence=1&isAllowed=y (24 April 2022, date last accessed).
  • 11. Shamseer L, Moher D, Clarke Met al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015; 349: g7647. 10.1136/bmj.g7647. [DOI] [PubMed] [Google Scholar]
  • 12. Higgins JP, Altman DG, Gøtzsche PCet al. The cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928. 10.1136/bmj.d5928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13. Wootton R, Gramotnev H, Hailey D. Telephone-supported care coordination in an Australian veteran population: a randomized controlled trial. J Telemed Telecare 2010; 16: 57–62. [DOI] [PubMed] [Google Scholar]
  • 14. Caplan GA, Williams AJ, Daly B, Abraham K. A randomized, controlled trial of comprehensive geriatric assessment and multidisciplinary intervention after discharge of elderly from the emergency department: the DEED II study. J Am Geriatr Soc 2004; 52: 1417–23. [DOI] [PubMed] [Google Scholar]
  • 15. Courtney M, Edwards H, Chang A, Parker A, Finlayson K, Hamilton K. Fewer emergency readmissions and better quality of life for older adults at risk of hospital readmission: a randomized controlled trial to determine the effectiveness of a 24-week exercise and telephone follow-up program. J Am Geriatr Soc 2009; 57: 395–402. [DOI] [PubMed] [Google Scholar]
  • 16. Basger BJ, Moles RJ, Chen TF. Impact of an enhanced pharmacy discharge service on prescribing appropriateness criteria: a randomised controlled trial. Int J Clin Pharmacol 2015; 37: 1194–205. [DOI] [PubMed] [Google Scholar]
  • 17. Crotty M, Whitehead CH, Wundke R, Giles LC, Ben-Tovim D, Phillips PA. Transitional care facility for elderly people in hospital awaiting a long term care bed: randomised controlled trial. BMJ 2005; 331: 1110. 10.1136/bmj.38638.441933.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18. Finlayson K, Chang AM, Courtney MDet al. Transitional care interventions reduce unplanned hospital readmissions in high-risk older adults. BMC Health Serv Res 2018; 18: 956. 10.1186/s12913-018-3771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19. Naylor MD, Brooten DA, Campbell RL, Maislin G, McCauley KM, Schwartz JS. Transitional care of older adults hospitalized with heart failure: a randomized, controlled trial. J Am Geriatr Soc 2004; 52: 675–84. [DOI] [PubMed] [Google Scholar]
  • 20. Nazareth I, Burton A, Shulman S, Smith P, Haines A, Timberal H. A pharmacy discharge plan for hospitalized elderly patients: a randomized controlled trial. Age Ageing 2001; 30: 33–40. [DOI] [PubMed] [Google Scholar]
  • 21. Man WD, Polkey MI, Donaldson N, Gray BJ, Moxham J. Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ 2004; 329: 1209. 10.1136/bmj.38258.662720.3A. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22. Sinclair AJ, Conroy SP, Davies M, Bayer AJ. Post-discharge home-based support for older cardiac patients: a randomised controlled trial. Age Ageing 2005; 34: 338–43. [DOI] [PubMed] [Google Scholar]
  • 23. Sahota O, Pulikottil-Jacob R, Marshall Fet al. The community in-reach rehabilitation and care transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency. Age Ageing 2017; 46: 26–32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24. Edmans J, Bradshaw L, Franklin M, Gladman J, Conroy S. Specialist geriatric medical assessment for patients discharged from hospital acute assessment units: randomised controlled trial. BMJ 2013; 347: f5874. 10.1136/bmj.f5874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25. Cunliffe AL, Gladman JR, Husbands SL, Miller P, Dewey ME, Harwood RH. Sooner and healthier: a randomised controlled trial and interview study of an early discharge rehabilitation service for older people. Age Ageing 2004; 33: 246–52. [DOI] [PubMed] [Google Scholar]
  • 26. Biese K, Lamantia M, Shofer Fet al. A randomized trial exploring the effect of a telephone call follow-up on care plan compliance among older adults discharged home from the emergency department. Acad Emerg Med 2014; 21: 188–95. [DOI] [PubMed] [Google Scholar]
  • 27. Saleh SS, Freire C, Morris-Dickinson G, Shannon T. An effectiveness and cost-benefit analysis of a hospital-based discharge transition program for elderly Medicare recipients. J Am Geriatr Soc 2012; 60: 1051–6. [DOI] [PubMed] [Google Scholar]
  • 28. Mion LC, Palmer RM, Meldon SWet al. Case finding and referral model for emergency department elders: a randomized clinical trial. Ann Emerg Med 2003; 41: 57–68. [DOI] [PubMed] [Google Scholar]
  • 29. Mukamel DB, Amin A, Weimer DLet al. Personalizing nursing home compare and the discharge from hospitals to nursing homes. Health Serv Res 2016; 51: 2076–94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30. Coleman EA, Parry C, Chalmers S, Min SJ. The care transitions intervention: results of a randomized controlled trial. Arch Intern Med 2006; 166: 1822–8. [DOI] [PubMed] [Google Scholar]
  • 31. Mayo NE, Nadeau L, Ahmed Set al. Bridging the gap: the effectiveness of teaming a stroke coordinator with patient's personal physician on the outcome of stroke. Age Ageing 2008; 37: 32–8. [DOI] [PubMed] [Google Scholar]
  • 32. Van Spall HGC, Lee SF, Xie Fet al. Effect of patient-centered transitional care services on clinical outcomes in patients hospitalized for heart failure: the PACT-HF randomized clinical trial. JAMA 2019; 321: 753–61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33. Rosstad T, Salvesen O, Steinsbekk A, Grimsmo A, Sletvold O, Garasen H. Generic care pathway for elderly patients in need of home care services after discharge from hospital: a cluster randomised controlled trial. BMC Health Serv Res 2017; 17: 275. 10.1186/s12913-017-2206-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34. Herfjord JK, Heggestad T, Ersland H, Ranhoff AH. Intermediate care in nursing home after hospital admission: a randomized controlled trial with one-year follow-up. BMC Res Notes 2014; 7: 889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35. López Cabezas C, Falces Salvador C, Cubí Quadrada Det al. Randomized clinical trial of a postdischarge pharmaceutical care program vs regular follow-up in patients with heart failure. Farm Hosp 2006; 30: 328–42. [DOI] [PubMed] [Google Scholar]
  • 36. Rytter L, Jakobsen HN, Ronholt Fet al. Comprehensive discharge follow-up in patients' homes by GPs and district nurses of elderly patients: a randomized controlled trial. Scand J Prim Health Care 2010; 28: 146–53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37. Wong FK, Chow SK, Chan TM, Tam SK. Comparison of effects between home visits with telephone calls and telephone calls only for transitional discharge support: a randomised controlled trial. Age Ageing 2014; 43: 91–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38. Freund Y, Cachanado M, Delannoy Qet al. Effect of an emergency department care bundle on 30-day hospital discharge and survival among elderly patients with acute heart failure: the ELISABETH randomized clinical trial. JAMA 2020; 324: 1948–56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39. Aimonino Ricauda N, Tibaldi V, Leff Bet al. Substitutive ‘hospital at home’ versus inpatient care for elderly patients with exacerbations of chronic obstructive pulmonary disease: a prospective randomized, controlled trial. J Am Geriatr Soc 2008; 56: 493–500. [DOI] [PubMed] [Google Scholar]
  • 40. Parsons M, Parsons J, Rouse Pet al. Supported discharge teams for older people in hospital acute care: a randomised controlled trial. Age Ageing 2018; 47: 288–94. [DOI] [PubMed] [Google Scholar]
  • 41. Leventhal ME, Denhaerynck K, Brunner-La Rocca HPet al. Swiss interdisciplinary management programme for heart failure (SWIM-HF): a randomised controlled trial study of an outpatient inter-professional management programme for heart failure patients in Switzerland. Swiss Med Wkly 2011; 141: w13171. 10.4414/smw.2011.13171. [DOI] [PubMed] [Google Scholar]
  • 42. González-Guerrero JL, Alonso-Fernández T, García-Mayolín N, Gusi N, Ribera-Casado JM. Effectiveness of a follow-up program for elderly heart failure patients after hospital discharge: a randomized controlled trial. Eur Geriatr Med 2014; 5: 252–7. [DOI] [PubMed] [Google Scholar]
  • 43. Hesselink G, Schoonhoven L, Barach Pet al. Improving patient handovers from hospital to primary care: a systematic review. Ann Intern Med 2012; 157: 417–28. [DOI] [PubMed] [Google Scholar]
  • 44. Leppin AL, Gionfriddo MR, Kessler Met al. Preventing 30-day hospital readmissions: a systematic review and meta-analysis of randomized trials. JAMA Intern Med 2014; 174: 1095–107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45. Nielsen M, Buelt L, Patel K, Nichols LM. The patient-centered medical home’s impact on cost and quality: annual review of evidence 2014–2015. 2016. https://www.pcpcc.org/resource/patient-centered-medicalhomes-impact-cost-and-quality-2014-2015 (24 April 2022, date last accessed).
  • 46. Spitzer S, Weber D. Reporting biases in self-assessed physical and cognitive health status of older Europeans. PLoS One 2019; 14: e0223526. 10.1371/journal.pone.0223526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47. Schwarz CM, Hoffmann M, Schwarz P, Kamolz LP, Brunner G, Sendlhofer G. A systematic literature review and narrative synthesis on the risks of medical discharge letters for patients' safety. BMC Health Serv Res 2019; 19: 158. 10.1186/s12913-019-3989-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 48. Barker I, Steventon A, Deeny SR. Association between continuity of care in general practice and hospital admissions for ambulatory care sensitive conditions: cross sectional study of routinely collected, person level data. BMJ 2017; 356: j84. 10.1136/bmj.j84. [DOI] [PubMed] [Google Scholar]
  • 49. Dicker D, Nguyen G, Abate Det al. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the global burden of disease study 2017. Lancet 2018; 392: 1684–735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 50. Panesar SS, DeSilva D, Carson-Stevens Aet al. How safe is primary care? A systematic review. BMJ Qual Saf 2016; 25: 544–53. [DOI] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

aa-22-0066-File002_afac151
Click here for additional data file. (53.5KB, docx)

Articles from Age and Ageing are provided here courtesy of Oxford University Press

RESOURCES