Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 26;20(5):782–793. doi: 10.1158/1541-7786.MCR-21-1037

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

PMC Copyright notice

Figure 4. PGS predicted ADT response or clinical outcomes in independent hormone-naïve or CRPC clinical cohorts. A, Single-sample gene set enrichment score of PGS is proportionally related to the residual tumor volumes [RCB, r(35) = 0.74, P < 0.00001] in primary hormone-naïve prostate cancer treated with preoperative ADT (Sowalsky clinical cohort, n = 37). B, In the Sowalsky cohort, the PGS gene set enrichment score is significantly higher in nonresponders (NR) compared with exceptional responders (ER; P < 0.0001) and incomplete responders (IR; P < 0.0001). C and D, Kaplan–Meier estimate of OS or PFS segregated according to the PGS score in SU2C (A, n = 60) and Alumkal (B, n = 25) clinical cohorts. In both cohorts, patients with PGS = 1 had worse outcome than those with PGS = 0 (P = 0.0002 and 0.006, respectively). E, Panther Protein Classification of the PGS genes revealed that the genes were involved in various biological processes. — PGS predicted ADT response or clinical outcomes in independent hormone-naïve or CRPC clinical cohorts. A, Single-sample gene set enrichment score of PGS is proportionally related to the residual tumor volumes [RCB, r(35) = 0.74, P < 0.00001] in primary hormone-naïve prostate cancer treated with preoperative ADT (Sowalsky clinical cohort, n = 37). B, In the Sowalsky cohort, the PGS gene set enrichment score is significantly higher in nonresponders (NR) compared with exceptional responders (ER; P < 0.0001) and incomplete responders (IR; P < 0.0001). C and D, Kaplan–Meier estimate of OS or PFS segregated according to the PGS score in SU2C (A,n = 60) and Alumkal (B,n = 25) clinical cohorts. In both cohorts, patients with PGS = 1 had worse outcome than those with PGS = 0 (P = 0.0002 and 0.006, respectively). E, Panther Protein Classification of the PGS genes revealed that the genes were involved in various biological processes.