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. 2022 Jun 19;2022:1590717. doi: 10.1155/2022/1590717

Figure 5.

Figure 5

Inhibition of CREB1 reversed the promotion of cell proliferation by TUFT1 overexpression. (a) Western blot analysis of FASN and SCD in TUFT1-overexpressing or knockdown cells. (b) Western blot analysis of p-CREB1, FASN, and SCD in TUFT1-overexpressing Huh7 cells, treated with KG-501 or vehicle control. (c) Upper panel: immunofluorescence of p-CREB1 (Ser133) in vector, TUFT1 overexpression, and KG-501-treated TUFT1-overexpressing Huh7 cells; down panel: BODIPY 493/503 dye staining in these cells. Scale bar: 10 μm. (d) Cell proliferation analysis of Huh7 cells, treated with KG-501 or vehicle control. ∗∗P < 0.01.