Table 3.

Univariable and multivariable Cox proportional-hazards model regarding each group of renin-angiotensin-aldosterone system inhibitor withdrawal and all-cause mortality.

Variable	HR	Std. Err.	p value	95% CI	HR	Std. Err.	p value	95% CI
ACEi withdrawal	1.40	0.17	0.010	1.10-1.79	1.62	0.23	<0.001	1.23-2.14
ARB withdrawal	1.25	0.16	0.080	0.97-1.60	1.25	0.19	0.140	0.93-1.68
MRA withdrawal	2.43	0.50	<0.001	1.62-3.63	2.10	0.50	<0.001	1.32-3.34
Age (per year)	1.06	0.01	<0.001	1.05-1.07	1.06	0.01	<0.001	1.04-1.07
Male sex	1.20	0.14	0.120	0.95-1.51	1.34	0.18	0.030	1.03-1.73
Hypertension	0.97	0.23	0.890	0.61-1.54	0.95	0.24	0.850	0.58-1.56
Diabetes Mellitus	1.19	0.14	0.149	0.94-1.49	1.07	0.14	0.580	0.83-1.38
Dyslipidemia	1.34	0.17	0.020	1.05-1.71	1.19	0.16	0.200	0.91-1.56
CHD	1.29	0.19	0.0860	0.96-1.73	0.78	0.16	0.220	0.52-1.16
HF	1.53	0.24	0.007	1.12-2.09	0.95	0.18	0.770	0.65-1.38
TIA/Stroke	1.60	0.25	0.003	1.17-2.18	1.14	0.19	0.424	0.82-1.58
PAD	1.63	0.25	0.001	1.21-2.19	1.43	0.31	0.092	0.94-2.18
CKD	1.61	0.24	0.001	1.20-2.15	0.94	0.15	0.680	0.68-1.29
Hydroxychloroquine	0.56	0.10	0.001	0.40-0.78	0.55	0.12	0.006	0.36-0.84
Lopinavir/Ritonavir	1.10	0.17	0.550	0.81-1.49	0.74	0.14	0.112	0.50-1.07
Azithromycin	0.62	0.07	<0.001	0.49-0.77	0.84	0.11	0.177	0.65-1.08
Corticosteroids	1.72	0.21	<0.001	1.36-2.18	1.85	0.24	<0.001	1.44-2.38

ACEi: angiotensin converting enzyme inhibitors; ARB: angiotensin receptor blockers; CHD: coronary heart disease; CKD: chronic kidney disease; CRP: C-reactive protein; HF: heart failure; MRA: mineralocorticoid receptor antagonists; PAD: peripheral artery disease; RAAS: renin-angiotensin-aldosterone system; TIA: transient ischemic attack.