Table 3.
Cross-sectional Imaging Features Association With Rutgeerts’ Score
| Factor | Overall (N = 216) | Rutgeerts’ score | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Statistics | i0 (n = 55) | i1 (n = 23) | i2a (n = 54) | i2b (n = 36) | i3 (n = 22) | i4 (n = 26) | ||
| Time from start time-point to matched endoscopy, d | 216 | 709.5 [351.5–1329.25] | 590.0 [245.5– 1011.5] | 797.0 [363.5–1094.5] | 709.5 [360.25–1660.75] | 917.0 [434.25–1329.25] | 556.0 [329.0–822.0] | 971.5 [540.0–1589.0] | .052a |
| Active disease sites proximal to neoTI | 216 | 40 (18.5) | 11 (20.0) | 4 (17.4) | 7 (13.0) | 6 (16.7) | 4 (18.2) | 8 (30.8) | .57c |
| Disease presence relative to neoTI, cm | 216 | .015c | |||||||
| No disease | 47 (21.8) | 20 (36.4)g | 7 (30.4) | 11 (20.4) | 5 (13.9) | 3 (13.6) | 1 (3.8)d | ||
| 0–5 | 163 (75.5) | 34 (61.8) | 14 (60.9) | 43 (79.6) | 29 (80.6) | 19 (86.4) | 24 (92.3) | ||
| 5–10 | 3 (1.4) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (5.6) | 0 (0.00) | 1 (3.8) | ||
| 10–20 | 1 (0.46) | 0 (0.00) | 1 (4.3) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | ||
| >20 | 2 (0.93) | 1 (1.8) | 1 (4.3) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | ||
| Intestinal wall thickening | 215 | 165 (76.7) | 33 (61.1) | 15 (65.2) | 42 (77.8) | 31 (86.1) | 19 (86.4) | 25 (96.2) | .004b |
| Luminal narrowing | 216 | 130 (60.2) | 23 (41.8) | 14 (60.9) | 33 (61.1) | 24 (66.7) | 17 (77.3) | 19 (73.1) | .025b |
| Hyper-enhancement | 216 | 158 (73.1) | 32 (58.2) | 12 (52.2) | 42 (77.8) | 30 (83.3) | 18 (81.8) | 24 (92.3) | .001b |
| Length of disease, cm | 216 | < .001c | |||||||
| No disease | 46 (21.3) | 19 (34.5)f,g | 7 (30.4) | 11 (20.4)g | 5 (13.9) | 3 (13.6)d | 1 (3.8)d,e | ||
| 1–10 | 114 (52.8) | 30 (54.5) | 9 (39.1) | 34 (63.0) | 23 (63.9) | 9 (40.9) | 9 (34.6) | ||
| >10 | 56 (25.9) | 6 (10.9) | 4 (30.4) | 9 (16.7) | 8 (22.3) | 10 (45.4) | 16 (61.5) | ||
| Upstream stasis >2.5 cm | 207 | 14 (6.8) | 4 (7.8) | 0 (0.00) | 5 (9.4) | 2 (5.7) | 2 (10.0) | 1 (3.8) | .70c |
| Upstream dilation >3 cm | 214 | 90 (42.1) | 15 (27.8) | 10 (43.5) | 18 (33.3) | 18 (51.4) | 14 (63.6) | 15 (57.7) | .014b |
| Mural fat | 213 | 37 (17.4) | 4 (7.4) | 6 (26.1) | 13 (24.1) | 8 (22.9) | 3 (13.6) | 3 (12.0) | .15c |
| Pseudosacculations | 214 | 13 (6.1) | 2 (3.6) | 2 (8.7) | 6 (11.3) | 2 (5.7) | 0 (0.00) | 1 (3.8) | .41c |
| Fibrofatty proliferation | 212 | 43 (20.3) | 9 (16.4) | 4 (17.4) | 9 (17.0) | 6 (18.2) | 8 (36.4) | 7 (26.9) | .38b |
| Penetrating disease | 215 | 10 (4.7) | 1 (1.8) | 0 (0.0) | 0 (0.0) | 4 (11.4) | 0 (0.0) | 5 (19.2) | .001c |
| Graded radiologic severity | 215 | < .001c | |||||||
| No | 51 (23.6) | 21 (38.2)f,g | 10 (43.5)g | 11 (20.4)g | 5 (13.9) | 3 (13.6) | 1 (3.8)d | ||
| Minimal | 48 (22.2) | 16 (29.1) | 4 (17.4) | 18 (33.3) | 7 (19.4) | 1 (4.5) | 2 (7.7) | ||
| Mild | 70 (32.4) | 12 (21.8) | 6 (26.1) | 17 (31.5) | 13 (36.1) | 14 (63.6) | 8 (30.8) | ||
| Moderate | 39 (18.1) | 5 (9.1) | 3 (13.0) | 6 (11.1) | 10 (27.8) | 3 (13.6) | 12 (46.2) | ||
| Severe | 8 (3.7) | 1 (1.8) | 0 (0.0) | 2 (3.7) | 1 (2.8) | 1 (4.5) | 3 (11.5) | ||
| Any radiologic activity | 216 | 165 (76.4) | 34 (61.8) | 13 (56.5) | 43 (79.6) | 31 (86.1) | 19 (86.4) | 25 (96.2) | .001b |
Note: Data are presented as median [IQR] or number (%).
Note: Boldface P-values indicate statistical significance.
IQR, Interquartile range; neoTI, neoterminal ileum.
a
P-values: Kruskal-Wallis test.
b
P-values: Pearson χ2 test.
c
P-values: Fisher exact test.
d
Significantly different from i0.
e
Significantly different from i2a.
f
Significantly different from i3.
g
Significantly different from i4.