Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 13;13:903565. doi: 10.3389/fneur.2022.903565

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Yu, Zheng, Cheng, Shao, Zhuge and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metformin, rapamycin, or NMN pretreatment ameliorates WMLs in BCCAO rats. (A) Representative images of Luxol fast blue (LFB) staining in the corpus callosum (CC), internal capsule (IC), and striatum (Str) in BCCAO or sham rats pretreated with vehicle (Veh), metformin (Met), rapamycin (Rapa), or NMN (NMN) at 2 weeks before surgery. (B–D) Quantitative analysis of WMLs in BCCAO or sham-operated rats after treatment. The extent of WMLs was graded as normal (Grade 0), disarrangement of nerve fibers (Grade 1), formation of marked vacuoles (Grade 2), and loss of myelinated fibers (Grade 3). All data were shown as mean ± SEM, n = 6 per group. The p-values were assessed by Kruskal–Wallis test with a Dunn post-test. 2VO, two-vessel occlusion.