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. 2022 Jun 13;13:917155. doi: 10.3389/fimmu.2022.917155

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Copyright © 2022 Zhang, Song, Jia, Tian, Lai, Zhang, Li, Ju and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The overlay map (A) and timeline view (B) of keywords related to necroptosis. (A) Keywords appeared ≥50, max lines = 200. The node size reflects the co-occurrence frequencies, the link indicates the co-occurrence relationship, the thickness of the link is proportional to the number of times two keywords co-occur, and the color indicates the average published year. (B) Each horizontal line represents a cluster; the smaller the number, the larger the cluster, and #0 is the largest. The time is at the top, and keywords are located at their first co-occurrence time in the cluster. Cluster labels were extracted from title and abstract information by LSI (red) and LLR (yellow). LSI, light semantic indexing; LLR, log-likelihood ratio; AD, Alzheimer’s disease; AKI, acute kidney injury; ALL, acute lymphoblastic leukemia; ALS, amyotrophic lateral sclerosis; AML, Acute Myelocytic leukemia; APP, amyloid precursor protein; bcl-2, B-cell lymphoma-2; er stress, endoplasmic reticulum stress; GM-CSF, granulocyte/macrophage colony-stimulating factor; GSDMD, gasdermin-D; HCC, hepatocellular carcinoma; IAP, inhibitors of apoptosis; IBD, inflammatory bowel disease; INF-γ, interferon-γ; MI, myocardial infarction; MLKL, mixed lineage kinase domain-like protein; NF-κB, nuclear factor κ-light-chain-enhancer of activated B cells; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3; PCD, programmed cell death; RIPK, receptor-interacting protein kinase; RIPK1, receptor-interacting protein kinase-1; RIPK3, receptor-interacting protein kinase-3; ROS, reactive oxygen species.