Table 6.

Top 15 molecules, pathological process and disease related to necroptosis.

Rank	Molecules	Counts	Pathological process	Counts	Diseases	Counts
1	MLKL	521	Cell-death	1,211	Cancer	170
2	TNF-alpha	358	Apoptosis	1,104	Ischemia/reperfusion injury	110
3	NF-κB	315	Necroptosis	885	Infection	50
4	RIPK3	233	Necrosis	557	Carcinoma	32
5	RIPK1	155	Inflammation	443	Alzheimer’s disease	31
6	Complex	89	Oxidative stress	273	Brain injury	30
7	Caspase-8	82	Phosphorylation	254	Fibrosis	26
8	NLRP3	65	Autophagy	204	Stroke	26
9	ROS	50	Proliferation	70	Acute kidney injury	25
10	FADD	38	ER stress	65	Breast cancer	25
11	Necrostatin-1	37	Ubiquitination	45	Tumor	23
12	Inflammasome	34	DNA damage	40	Drug resistance	22
13	p53	33	Pyroptosis	26	Hepatocellular carcinoma	22
14	bcl-2	32	Ferroptosis	25	Inflammatory bowel disease	20
15	Toll-like receptors	19	Mitophagy	19	Parkinson’s disease	19

MLKL, mixed lineage kinase domain-like protein; TNF-alpha, tumor necrosis factor-alpha; NF-κB, nuclear factor κ-light-chain-enhancer of activated B cells; RIPK3, receptor-interacting protein kinase-3; RIPK1, receptor-interacting protein kinase-1; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3; ROS, reactive oxygen species; FADD, Fas-associated via death domain; er stress, endoplasmic reticulum stress; bcl-2, B-cell lymphoma-2.