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. 2022 Jun 13;13:923263. doi: 10.3389/fgene.2022.923263

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Copyright © 2022 Liu, Zhu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined survival analysis of risk scores and key cancer hallmarks in the training set. (A) Hypoxia and angiogenesis z-scores were significantly higher in the high-risk group. (B) HIF1A and VEGFA expression levels were significantly higher in the high-risk group. (C,D) The prognosis was worse in patients with high risk scores and high hypoxia or angiogenesis z-scores, according to KM analysis for OS after combining risk scores and key cancer hallmarks. (E,F) The prognosis was worse in patients with high risk scores and high HIF1A or VEGFA expression, based on KM analysis for OS after combining risk scores and genes related to key cancer hallmarks.