Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 13;13:903259. doi: 10.3389/fphar.2022.903259

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhou, Li, Luo, Zhu, Zhao, Wang, Sang, Chang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Allicin acts against digestive system cancers in vitro. The anticancer effect of allicin in vitro is mainly reflected in five aspects, including inhibiting proliferation, inducing apoptosis, inducing autophagy, inhibiting angiogenesis, invasion, and metastasis, and enhancing the sensitivity of tumor chemotherapy. It depletes intracellular glutathione (GSH) and up-regulates p21WAF1 and p16INK4 genes to block the cell cycle and inhibit cell proliferation. It activates both endogenous and exogenous apoptotic pathways by regulating intracellular signaling pathways, inhibiting telomerase activity, and regulating the activity of apoptosis-related proteins. In addition, it also down-regulates the PI3K/mTOR signaling pathway and up-regulates the AMPK/TSC2 and Beclin-1 signaling pathways to induce the P53 mediated autophagy. It inhibits tumor angiogenesis, migration, and metastasis by down-regulating VEGF, u-PAR, and HPA. Moreover, via ROS -mediated mitochondrial pathway, it exerts the chemosensitization effect towards tumor cells.