TABLE 2.
Different endogenous metabolites in rat urine.
| No. | Metabolites | Retention time (min) | Formula | CUMS/NC | PF/CUMS |
|---|---|---|---|---|---|
| 1 | Citric acid | 1.3882 | C6H8O7 | ↓** | ↑## |
| 2 | 12-oxo-5E,8E,10Z-dodecatrienoic acid | 4.9219 | C12H16O3 | ↑** | ↓## |
| 3 | (+/-)-Hexanoylcarnitine | 4.3347 | C13H25NO4 | ↑** | ↓## |
| 4 | Blumenol C glucoside | 4.7034 | C19H32O7 | ↑** | ↓# |
| 5 | (1R,4R)-Dihydrocarvone | 5.9385 | C10H16O | ↑** | ↓# |
| 6 | S-Nitrosoglutathione | 2.8026 | C10H16N4O7S | ↑** | ↓# |
| 7 | (R)-(-)-Mellein | 1.7491 | C10H10O3 | ↓** | ↑## |
| 8 | 1-(Malonylamino)cyclopropanecarboxylic acid | 1.8034 | C7H9NO5 | ↓** | ↑## |
| 9 | Biopterin | 1.8238 | C9H11N5O3 | ↑** | ↓## |
| 10 | {[1-(2-hydroxyphenyl)-3-oxopropan-2-yl]oxy}sulfonic acid | 3.0543 | C9H10O6S | ↓** | ↑## |
| 11 | 6-{4-[(1E)-3-[(3-carboxy-5,6-dihydroxycyclohex-3-en-1-yl)oxy]-3-oxoprop-1-en-1-yl]-2-hydroxyphenoxy}-3,4,5-trihydroxyoxane-2-carboxylic acid | 3.1494 | C22H24O14 | ↓** | ↑## |
| 12 | 3-carboxy-4-methyl-5-pentyl-2-furanpropanoic acid | 3.3253 | C14H20O5 | ↑** | ↓## |
| 13 | Alanyl-Proline | 4.2321 | C8H14N2O3 | ↑** | ↓## |
| 14 | Tranylcypromine glucuronide | 4.2526 | C15H19NO6 | ↑** | ↓## |
| 15 | (Z)-3-Oxo-2-(2-pentenyl)-1-cyclopenteneacetic acid | 4.4713 | C12H16O3 | ↑** | ↓# |
| 16 | 3-Hydroxytetradecanedioic acid | 5.0311 | C14H26O5 | ↑** | ↓## |
| 17 | O-Desmethylvenlafaxine glucuronide | 5.8158 | C20H29NO8 | ↑** | ↓# |
| 18 | 10-Hydroxymyoporone | 5.9385 | C15H22O4 | ↑** | ↓# |
| 19 | 13Z-Docosenamide | 6.5628 | C22H43NO | ↓** | ↑# |
| 20 | 5-(hydroxymethyl)-2-Furancarboxylic acid | 9.9531 | C6H6O4 | ↓** | ↑## |
| 21 | N-Acetyltyramine | 5.6997 | C10H13NO2 | ↑** | ↓## |
| 22 | Tsangane L 3-glucoside | 5.5905 | C19H34O7 | ↑** | ↓## |
| 23 | 4-Isopentylphenol | 5.5768 | C11H16O | ↑** | ↓# |
| 24 | Trigoforin | 5.4881 | C12H12O2 | ↑** | ↓## |
| 25 | 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethan-1-ol | 5.1541 | C24H24O2 | ↓** | ↓# |
| 26 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | 4.7374 | C16H16N2O4 | ↑** | ↓## |
| 27 | Dihydromaleimide beta-D-glucoside | 4.6628 | C10H15NO7 | ↓** | ↑# |
| 28 | 3,8-Dihydroxy-6-methoxy-7 (11)-eremophilen-12,8-olide | 4.6559 | C16H24O5 | ↑** | ↓## |
| 29 | Cis-2,3-Dihydroxy-2,3-dihydro-p-cumate | 4.2526 | C10H14O4 | ↓** | ↑## |
| 30 | Erysonine | 4.1433 | C17H19NO3 | ↑** | ↓## |
| 31 | 4-hydroxy-5-(4-hydroxy-3-methoxyphenyl)pentanoic acid | 3.8706 | C12H16O5 | ↑** | ↓# |
| 32 | 2,6-Dioxo-6-phenylhexanoate | 3.7752 | C12H12O4 | ↑** | ↓## |
| 33 | Thioacetate | 3.693 | C2H4OS | ↑** | ↓# |
| 34 | (5R)-5-Hydroxyhexanoic acid | 3.2167 | C6H12O3 | ↑** | ↓# |
| 35 | Veranisatin A | 3.1494 | C16H22O8 | ↓** | ↑## |
| 36 | 5-Hydroxy-2-(5-methyl-1-oxo-4-hexenyl)benzofuran | 2.3819 | C15H16O3 | ↑** | ↓# |
| 37 | 2-Methoxyhydroquinone | 2.2798 | C7H8O3 | ↓** | ↑# |
| 38 | 5′-Deoxyadenosine | 1.9395 | C10H13N5O3 | ↑* | ↓## |
| 39 | N-(2-Hydroxyethyl)iminodiacetic acid | 0.6368 | C6H11NO5 | ↓** | ↑# |
| 40 | Quinone | 2.0213 | C6H4O2 | ↓** | ↑# |
| 41 | Stachyose | 0.8169 | C24H42O21 | ↓** | ↑## |
| 42 | Thiamine monophosphate | 1.9084 | C12H17N4O4PS | ↓** | ↑## |
| 43 | Gluconolactone | 2.7931 | C6H10O6 | ↓** | ↑## |
| 44 | 4-Hydroxy-5-(phenyl)-valeric acid-O-sulphate | 4.0312 | C11H14O6S | ↑** | ↓# |
| 45 | Beta-D-Glucopyranosyl-11-hydroxyjasmonic acid | 4.2413 | C18H28O9 | ↑** | ↓## |
| 46 | Valproic acid glucuronide | 5.2494 | C14H24O8 | ↑** | ↓## |
| 47 | 9,15-dioxo-11R-hydroxy-2,3,4,5-tetranor-prostan-1,20-dioic acid | 5.5638 | C16H24O7 | ↓** | ↓## |
| 48 | {[1-(4-methoxyphenyl)-4-methylpent-1-en-3-yl]oxy}sulfonic acid | 5.487 | C13H18O5S | ↑** | ↓## |
| 49 | Xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside | 5.3754 | C17H24O8 | ↑** | ↓## |
| 50 | Alpha-CEHC glucuronide | 5.0472 | C22H30O10 | ↑** | ↓# |
| 51 | 6-(4-ethyl-2-methoxyphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid | 4.9778 | C15H20O8 | ↑** | ↓# |
| 52 | 1,4-Ipomeadiol | 3.9826 | C9H14O3 | ↑** | ↓# |
| 53 | {4-[(E)-2-{3,5-dihydroxy-4-[(1E)-3-methylbuta-1,3-dien-1-yl]phenyl}ethenyl]phenyl}oxidanesulfonic acid | 3.4771 | C19H18O6S | ↓** | ↑# |
| 54 | 5-Hydroxyindoleacetic acid | 3.3727 | C10H9NO3 | ↓** | ↑## |
| 55 | Trans-Chlorogenic acid | 2.8821 | C16H18O9 | ↓* | ↓## |
| 56 | 3,4,5-trihydroxy-6-[(2-hydroxy-2-methylpropanoyl)oxy]oxane-2-carboxylic acid | 1.6639 | C10H16O9 | ↑** | ↓# |
↑ represents up-regulation, ↓ represents down-regulation. **p < 0.01 and *p < 0.05, CUMS group versus NC group. ## p < 0.01 and # p < 0.05, PF group versus CUMS group.